Telomelysin shows potent antitumor activity through apoptotic and non-apoptotic cell death in soft tissue sarcoma cells

Gui Dong Li, Hiroyuki Kawashima, Akira Ogose, Takashi Ariizumi, Tetsuo Hotta, Ryozo Kuwano, Yasuo Urata, Toshiyoshi Fujiwara, Naoto Endo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study investigated the pathway underlying the antitumor activity of telomelysin, a telomerase-dependent, replication-selective oncolytic adenovirus, in soft tissue sarcoma cells. Treatment with telomelysin alone resulted in simultaneous induction of apoptosis and autophagy, whereas cotreatment with telomelysin and 3-methyladenine significantly reduced cell viability and increased apoptosis and the cellular ATP level compared to treatment with telomelysin alone, indicating that telomelysin-mediated autophagy is a death-protective but not death-promoting process. Cotreatment with Z-Val-Ala-Asp-CH2F significantly increased cellular ATP depletion compared to telomelysin-alone treatment while inhibiting telomelysin-induced apoptosis and having no significant effect on cell viability, indicating that it promotes transition from apoptotic to necrotic cell death.

Original languageEnglish
Pages (from-to)1178-1188
Number of pages11
JournalCancer Science
Volume104
Issue number9
DOIs
Publication statusPublished - Sep 2013

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Li, G. D., Kawashima, H., Ogose, A., Ariizumi, T., Hotta, T., Kuwano, R., Urata, Y., Fujiwara, T., & Endo, N. (2013). Telomelysin shows potent antitumor activity through apoptotic and non-apoptotic cell death in soft tissue sarcoma cells. Cancer Science, 104(9), 1178-1188. https://doi.org/10.1111/cas.12208