tele‐Methylhistamine Levels and Histamine Turnover in Nuclei of the Rat Hypothalamus and Amygdala

Yoshinori Itoh, Ryozo Oishi, Masahiro Nishibori, Kiyomi Saeki

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Abstract

An HPLC method using fluorescence detection for the determination of tele‐methylhistamine! (t‐MH) was improved to a sensitivity level which enabled the detection of 0.05 pmol of tissue t‐MH. The t‐MH contents and the histamine turnover rates in various nuclei of the rat hypothalamus and amygdala were subsequently measured. The histamine turnover rates were estimated from pargyline‐induced t‐MH accumulation. Both the t‐MH levels and the histamine turnover rates were shown to be relatively high in the nuclei dorsomedialis and premammillaris ventralis of the hypothalamus, and also in the nucleus medialis of the amygdala. The steady‐state t‐MH levels in various nuclei of the hypothalamus and amygdala correlated well with the histamine turnover rates in these nuclei.

Original languageEnglish
Pages (from-to)844-848
Number of pages5
JournalJournal of Neurochemistry
Volume53
Issue number3
DOIs
Publication statusPublished - Sep 1989

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Keywords

  • Amygdala
  • Histamine turnover
  • Hypothalamus
  • Pargyline
  • tele‐Methylhista‐mine

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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