Tectona grandis callus produces antibacterial triterpene acids not detected in the intact plant

E. Marwani, A. Kobayashi, S. I. Kajiyama, E. Fukusaki, Teruhiko Nitoda, Hiroshi Kanzaki, K. Kawazu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Preliminary antibacterial assay data that the Tectona grandis callus extract showed more antibacterial activity against E. coli and B. subtilis than the leaf extract led the authors to isolate the following antibacterial compounds from the callus. A mixture (3) of 2α,3β-dihydroxy-olean-12-en-28-oic acid (3b) and 2α,3β-dihydroxy-urs-12-en-28-oic acid (3b) exhibited the most potent antibacterial activity against both bacteria. The other 3 compounds, in the decreasing order of the activity, were identified as 2α,3α-dihydroxy-urs-12-en-28-oic acid (2), betulinic acid (1), and 2α,3α 23-trihydroxy-urs-12-en-28-oic acid (4). The antibacterial compounds (2, 3a, 3b and 4) were not detected or occurring in small quantities in the intact tissue, while they were observed in the callus. Only the less active compound 1 was present more abundantly in intact tissues than the callus.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalNatural Product Sciences
Volume3
Issue number1
Publication statusPublished - 1997

Fingerprint

Triterpenes
Bony Callus
Acids
Tissue
Escherichia coli
Assays
Bacteria

Keywords

  • Antibacterial compounds
  • Lupene
  • Oleanene
  • Tectona grandis callus
  • Triterpene acids
  • Ursene

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Marwani, E., Kobayashi, A., Kajiyama, S. I., Fukusaki, E., Nitoda, T., Kanzaki, H., & Kawazu, K. (1997). Tectona grandis callus produces antibacterial triterpene acids not detected in the intact plant. Natural Product Sciences, 3(1), 75-80.

Tectona grandis callus produces antibacterial triterpene acids not detected in the intact plant. / Marwani, E.; Kobayashi, A.; Kajiyama, S. I.; Fukusaki, E.; Nitoda, Teruhiko; Kanzaki, Hiroshi; Kawazu, K.

In: Natural Product Sciences, Vol. 3, No. 1, 1997, p. 75-80.

Research output: Contribution to journalArticle

Marwani, E, Kobayashi, A, Kajiyama, SI, Fukusaki, E, Nitoda, T, Kanzaki, H & Kawazu, K 1997, 'Tectona grandis callus produces antibacterial triterpene acids not detected in the intact plant', Natural Product Sciences, vol. 3, no. 1, pp. 75-80.
Marwani E, Kobayashi A, Kajiyama SI, Fukusaki E, Nitoda T, Kanzaki H et al. Tectona grandis callus produces antibacterial triterpene acids not detected in the intact plant. Natural Product Sciences. 1997;3(1):75-80.
Marwani, E. ; Kobayashi, A. ; Kajiyama, S. I. ; Fukusaki, E. ; Nitoda, Teruhiko ; Kanzaki, Hiroshi ; Kawazu, K. / Tectona grandis callus produces antibacterial triterpene acids not detected in the intact plant. In: Natural Product Sciences. 1997 ; Vol. 3, No. 1. pp. 75-80.
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