Tea catechins inhibit cell proliferation through hydrogen peroxide-dependent and -independent pathways in human T lymphocytic leukemia Jurkat cells

Yue Tang, Naomi Abe, Hang Qi, Beiwei Zhu, Yoshiyuki Murata, Yoshimasa Nakamura

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4 Citations (Scopus)


In the present study, we investigated the anti-proliferative effects of four tea catechins: (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECg) and (-)-epigallocatechin gallate (EGCg) in human T lymphocytic leukemia Jurkat cells. Each catechin induced a significant cytotoxic effect on Jurkat cells. Combinations of EGCg with other catechins additively potentiated anti-proliferation, extracellular hydrogen peroxide formation, c-Jun N-terminal kinase (JNK) activation and interferon (IFN)-γ mRNA expression. Catalase partly but significantly abolished the cytotoxicity induced by EGC or EGCg, whereas it did not influence the EC- or ECg-induced effect. Among the tea catechins, ECg synergistically enhanced the EGCg-induced JNK phosphorylation and IFN-γ expression. The present findings provide evidence that tea catechins are able to concertedly induce cytotoxicity through the JNK/IFN-γ pathway in both a hydrogen peroxide-dependent and -independent manner.

Original languageEnglish
Pages (from-to)1245-1249
Number of pages5
JournalFood Science and Technology Research
Issue number6
Publication statusPublished - Jan 1 2014



  • Cytotoxicity
  • Hydrogen peroxide
  • Interferon-γ
  • Jurkat cells
  • Tea catechins
  • c-Jun N-terminal kinase

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Marketing

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