Tau-negative astrocytic star-like inclusions and coiled bodies in dementia with Lewy bodies

S. Terada, H. Ishizu, T. Haraguchi, Y. Takehisa, Y. Tanabe, K. Kawai, S. Kuroda

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To evaluate glial lesions in cases of dementia with Lewy bodies (DLB), we studied the brains of four patients with DLB. Astrocytic star-like inclusions, which resembled tufted astrocytic fibrillary tangles in shape, were found in the cortex of two of these cases. In addition, coiled bodies were found in the white matter of the cerebrum in two cases. The astrocytic star-like inclusions were immunohistochemically negative for tau protein, ubiquitin and α-synuclein. The coiled bodies were immunohistochemically negative for tau protein but immunopositive for ubiquitin and α-synuclein. These results suggest that in DLB a primary degenerative process takes place in both glial cells and neurons.

Original languageEnglish
Pages (from-to)464-468
Number of pages5
JournalActa neuropathologica
Volume100
Issue number5
DOIs
Publication statusPublished - Sep 27 2000

Keywords

  • Astrocytic star-like inclusions
  • Coiled bodies
  • Dementia with Lewy bodies
  • Tau
  • α-Synuclein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Tau-negative astrocytic star-like inclusions and coiled bodies in dementia with Lewy bodies'. Together they form a unique fingerprint.

  • Cite this

    Terada, S., Ishizu, H., Haraguchi, T., Takehisa, Y., Tanabe, Y., Kawai, K., & Kuroda, S. (2000). Tau-negative astrocytic star-like inclusions and coiled bodies in dementia with Lewy bodies. Acta neuropathologica, 100(5), 464-468. https://doi.org/10.1007/s004010000213