Tau-negative astrocytic star-like inclusions and coiled bodies in dementia with Lewy bodies

Seishi Terada, H. Ishizu, T. Haraguchi, Y. Takehisa, Y. Tanabe, K. Kawai, S. Kuroda

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To evaluate glial lesions in cases of dementia with Lewy bodies (DLB), we studied the brains of four patients with DLB. Astrocytic star-like inclusions, which resembled tufted astrocytic fibrillary tangles in shape, were found in the cortex of two of these cases. In addition, coiled bodies were found in the white matter of the cerebrum in two cases. The astrocytic star-like inclusions were immunohistochemically negative for tau protein, ubiquitin and α-synuclein. The coiled bodies were immunohistochemically negative for tau protein but immunopositive for ubiquitin and α-synuclein. These results suggest that in DLB a primary degenerative process takes place in both glial cells and neurons.

Original languageEnglish
Pages (from-to)464-468
Number of pages5
JournalActa Neuropathologica
Volume100
Issue number5
DOIs
Publication statusPublished - 2000

Fingerprint

Coiled Bodies
Lewy Body Disease
Inclusion Bodies
Synucleins
tau Proteins
Ubiquitin
Neuroglia
Cerebrum
Neurons
Brain

Keywords

  • α-Synuclein
  • Astrocytic star-like inclusions
  • Coiled bodies
  • Dementia with Lewy bodies
  • Tau

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Terada, S., Ishizu, H., Haraguchi, T., Takehisa, Y., Tanabe, Y., Kawai, K., & Kuroda, S. (2000). Tau-negative astrocytic star-like inclusions and coiled bodies in dementia with Lewy bodies. Acta Neuropathologica, 100(5), 464-468. https://doi.org/10.1007/s004010000213

Tau-negative astrocytic star-like inclusions and coiled bodies in dementia with Lewy bodies. / Terada, Seishi; Ishizu, H.; Haraguchi, T.; Takehisa, Y.; Tanabe, Y.; Kawai, K.; Kuroda, S.

In: Acta Neuropathologica, Vol. 100, No. 5, 2000, p. 464-468.

Research output: Contribution to journalArticle

Terada, S, Ishizu, H, Haraguchi, T, Takehisa, Y, Tanabe, Y, Kawai, K & Kuroda, S 2000, 'Tau-negative astrocytic star-like inclusions and coiled bodies in dementia with Lewy bodies', Acta Neuropathologica, vol. 100, no. 5, pp. 464-468. https://doi.org/10.1007/s004010000213
Terada, Seishi ; Ishizu, H. ; Haraguchi, T. ; Takehisa, Y. ; Tanabe, Y. ; Kawai, K. ; Kuroda, S. / Tau-negative astrocytic star-like inclusions and coiled bodies in dementia with Lewy bodies. In: Acta Neuropathologica. 2000 ; Vol. 100, No. 5. pp. 464-468.
@article{b633752a982a404f90bbde72edf601d2,
title = "Tau-negative astrocytic star-like inclusions and coiled bodies in dementia with Lewy bodies",
abstract = "To evaluate glial lesions in cases of dementia with Lewy bodies (DLB), we studied the brains of four patients with DLB. Astrocytic star-like inclusions, which resembled tufted astrocytic fibrillary tangles in shape, were found in the cortex of two of these cases. In addition, coiled bodies were found in the white matter of the cerebrum in two cases. The astrocytic star-like inclusions were immunohistochemically negative for tau protein, ubiquitin and α-synuclein. The coiled bodies were immunohistochemically negative for tau protein but immunopositive for ubiquitin and α-synuclein. These results suggest that in DLB a primary degenerative process takes place in both glial cells and neurons.",
keywords = "α-Synuclein, Astrocytic star-like inclusions, Coiled bodies, Dementia with Lewy bodies, Tau",
author = "Seishi Terada and H. Ishizu and T. Haraguchi and Y. Takehisa and Y. Tanabe and K. Kawai and S. Kuroda",
year = "2000",
doi = "10.1007/s004010000213",
language = "English",
volume = "100",
pages = "464--468",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Tau-negative astrocytic star-like inclusions and coiled bodies in dementia with Lewy bodies

AU - Terada, Seishi

AU - Ishizu, H.

AU - Haraguchi, T.

AU - Takehisa, Y.

AU - Tanabe, Y.

AU - Kawai, K.

AU - Kuroda, S.

PY - 2000

Y1 - 2000

N2 - To evaluate glial lesions in cases of dementia with Lewy bodies (DLB), we studied the brains of four patients with DLB. Astrocytic star-like inclusions, which resembled tufted astrocytic fibrillary tangles in shape, were found in the cortex of two of these cases. In addition, coiled bodies were found in the white matter of the cerebrum in two cases. The astrocytic star-like inclusions were immunohistochemically negative for tau protein, ubiquitin and α-synuclein. The coiled bodies were immunohistochemically negative for tau protein but immunopositive for ubiquitin and α-synuclein. These results suggest that in DLB a primary degenerative process takes place in both glial cells and neurons.

AB - To evaluate glial lesions in cases of dementia with Lewy bodies (DLB), we studied the brains of four patients with DLB. Astrocytic star-like inclusions, which resembled tufted astrocytic fibrillary tangles in shape, were found in the cortex of two of these cases. In addition, coiled bodies were found in the white matter of the cerebrum in two cases. The astrocytic star-like inclusions were immunohistochemically negative for tau protein, ubiquitin and α-synuclein. The coiled bodies were immunohistochemically negative for tau protein but immunopositive for ubiquitin and α-synuclein. These results suggest that in DLB a primary degenerative process takes place in both glial cells and neurons.

KW - α-Synuclein

KW - Astrocytic star-like inclusions

KW - Coiled bodies

KW - Dementia with Lewy bodies

KW - Tau

UR - http://www.scopus.com/inward/record.url?scp=0033817832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033817832&partnerID=8YFLogxK

U2 - 10.1007/s004010000213

DO - 10.1007/s004010000213

M3 - Article

C2 - 11045667

AN - SCOPUS:0033817832

VL - 100

SP - 464

EP - 468

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 5

ER -