Targeting of post-ischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferrin

Nobuhiko Omori, K. Maruyama, G. Jin, F. Li, S. J. Wang, Y. Hamakawa, K. Sato, I. Nagano, M. Shoji, K. Abe

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

To achieve an efficient delivery targeting to post-ischemic cerebral vascular endothelium, PEG-liposome conjugated with transferrin (Tf) (Tf-PEG-liposome) was intravenously administered to the rats after 90 min of transient middle cerebral occlusion. The expression of Tf receptor (TfR) in the cerebral endothelium increased with a peak at 1 day after the reperfusion and returned to the control level by 6 days. The Tf-PEG fluorescence was marginally detectable in sham control brain, but remarkably increased with a peak at 2 days, showing about 70% of TfR positive vascular endothelium double-labeled with Tf-PEG. These results indicate that the Tf-PEG-liposome could be utilized as an efficient drug delivery tool to the brain after stroke.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalNeurological Research
Volume25
Issue number3
DOIs
Publication statusPublished - Apr 1 2003

Keywords

  • CM-Dil
  • Drug delivery system
  • Liposome
  • MCAO
  • Transferrin receptor

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Omori, N., Maruyama, K., Jin, G., Li, F., Wang, S. J., Hamakawa, Y., Sato, K., Nagano, I., Shoji, M., & Abe, K. (2003). Targeting of post-ischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferrin. Neurological Research, 25(3), 275-279. https://doi.org/10.1179/016164103101201508