Targeting hedgehog (Hh) pathway for the acute myeloid leukemia treatment

Toshiki Terao, Yosuke Minami

Research output: Contribution to journalReview articlepeer-review

31 Citations (Scopus)

Abstract

The Hedgehog (Hh) pathway, containing the Patched (PTCH) and Smoothened (SMO) multitransmembrane proteins, is the main regulator of vertebrate embryonic development. A noncanonical Hh pathway was recently observed in numerous types of solid cancers and hematological malignancies. Although acute myeloid leukemia (AML) is a common and lethal myeloid malignancy, the chemotherapy for AML has not changed in the last three decades. The Hh pathway and other intracellular signaling pathways are important for the tumor cells’ cycle or therapeutic resistance of AML cells. In this article, we will review the current trends in Hh pathway inhibitors for treating AML.

Original languageEnglish
Article number312
JournalCells
Volume8
Issue number4
DOIs
Publication statusPublished - Apr 2019
Externally publishedYes

Keywords

  • Acute myeloid leukemia
  • AML
  • Glasdegib
  • Glioma
  • Hedgehog pathway
  • Leukemic stem cell
  • Smoothened
  • Sonidegib

ASJC Scopus subject areas

  • Medicine(all)

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