Target of triglycerides as residual risk for cardiovascular events in patients with coronary artery disease: Post hoc analysis of the FMD-J study A

Masato Kajikawa, Tatsuya Maruhashi, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yuji Takaeko, Farina Mohamad Yusoff, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Kensuke Noma, Ayumu Nakashima, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo FurumotoKazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Itoh, Hisao Ikeda, Akira Yamashina, Yukihito Higashi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Circulating triglyceride (TG) levels are a current focus as a residual risk for cardiovascular (CV) events. We evaluated the relationship between circulating TG levels and future CV events in patients with coronary artery disease (CAD) who were treated with conventional therapy. Methods and Results: We analyzed data for 652 patients who were enrolled in the FMD-J Study A. We investigated the associations between serum TG levels and first major CV events (death from CV cause, nonfatal acute coronary syndrome (ACS), nonfatal stroke, and CAD) for a 3-year follow-up period. Patients were divided into 4 groups based on serum TG level: low-normal (<100 mg/dL), high-normal (100-149 mg/dL), borderline hypertriglyceridemia (150-199 mg/dL), and moderate hypertriglyceridemia (≥200 mg/dL). During a median follow-up period of 46.6 months, 14 patients died (9 from CV causes), 16 had nonfatal ACS, 6 had nonfatal stroke, and 54 had CAD. The Kaplan-Meier curves for first major CV event among the 4 groups were significantly different (P=0.04). After adjustment for various confounders, serum TG level ≥100 mg/dL were significantly associated with an increased risk of first major CV events compared with serum TG level <100 mg/dL. Conclusions: Serum TG level may be a surrogate marker for predicting CV events in patients with CAD.

Original languageEnglish
Pages (from-to)1064-1071
Number of pages8
JournalCirculation Journal
Volume83
Issue number5
DOIs
Publication statusPublished - Jan 1 2019

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Coronary Artery Disease
Triglycerides
Serum
Hypertriglyceridemia
Acute Coronary Syndrome
Stroke
Cause of Death
Biomarkers

Keywords

  • Atherosclerosis
  • Cardiovascular events
  • Triglycerides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Target of triglycerides as residual risk for cardiovascular events in patients with coronary artery disease : Post hoc analysis of the FMD-J study A. / Kajikawa, Masato; Maruhashi, Tatsuya; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Takaeko, Yuji; Yusoff, Farina Mohamad; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Noma, Kensuke; Nakashima, Ayumu; Tomiyama, Hirofumi; Takase, Bonpei; Kohro, Takahide; Suzuki, Toru; Ishizu, Tomoko; Ueda, Shinichiro; Yamazaki, Tsutomu; Furumoto, Tomoo; Kario, Kazuomi; Inoue, Teruo; Koba, Shinji; Watanabe, Kentaro; Takemoto, Yasuhiko; Hano, Takuzo; Sata, Masataka; Ishibashi, Yutaka; Node, Koichi; Maemura, Koji; Ohya, Yusuke; Furukawa, Taiji; Itoh, Hiroshi; Ikeda, Hisao; Yamashina, Akira; Higashi, Yukihito.

In: Circulation Journal, Vol. 83, No. 5, 01.01.2019, p. 1064-1071.

Research output: Contribution to journalArticle

Kajikawa, M, Maruhashi, T, Kishimoto, S, Matsui, S, Hashimoto, H, Takaeko, Y, Yusoff, FM, Kihara, Y, Chayama, K, Goto, C, Noma, K, Nakashima, A, Tomiyama, H, Takase, B, Kohro, T, Suzuki, T, Ishizu, T, Ueda, S, Yamazaki, T, Furumoto, T, Kario, K, Inoue, T, Koba, S, Watanabe, K, Takemoto, Y, Hano, T, Sata, M, Ishibashi, Y, Node, K, Maemura, K, Ohya, Y, Furukawa, T, Itoh, H, Ikeda, H, Yamashina, A & Higashi, Y 2019, 'Target of triglycerides as residual risk for cardiovascular events in patients with coronary artery disease: Post hoc analysis of the FMD-J study A', Circulation Journal, vol. 83, no. 5, pp. 1064-1071. https://doi.org/10.1253/circj.CJ-18-1082
Kajikawa, Masato ; Maruhashi, Tatsuya ; Kishimoto, Shinji ; Matsui, Shogo ; Hashimoto, Haruki ; Takaeko, Yuji ; Yusoff, Farina Mohamad ; Kihara, Yasuki ; Chayama, Kazuaki ; Goto, Chikara ; Noma, Kensuke ; Nakashima, Ayumu ; Tomiyama, Hirofumi ; Takase, Bonpei ; Kohro, Takahide ; Suzuki, Toru ; Ishizu, Tomoko ; Ueda, Shinichiro ; Yamazaki, Tsutomu ; Furumoto, Tomoo ; Kario, Kazuomi ; Inoue, Teruo ; Koba, Shinji ; Watanabe, Kentaro ; Takemoto, Yasuhiko ; Hano, Takuzo ; Sata, Masataka ; Ishibashi, Yutaka ; Node, Koichi ; Maemura, Koji ; Ohya, Yusuke ; Furukawa, Taiji ; Itoh, Hiroshi ; Ikeda, Hisao ; Yamashina, Akira ; Higashi, Yukihito. / Target of triglycerides as residual risk for cardiovascular events in patients with coronary artery disease : Post hoc analysis of the FMD-J study A. In: Circulation Journal. 2019 ; Vol. 83, No. 5. pp. 1064-1071.
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abstract = "Background: Circulating triglyceride (TG) levels are a current focus as a residual risk for cardiovascular (CV) events. We evaluated the relationship between circulating TG levels and future CV events in patients with coronary artery disease (CAD) who were treated with conventional therapy. Methods and Results: We analyzed data for 652 patients who were enrolled in the FMD-J Study A. We investigated the associations between serum TG levels and first major CV events (death from CV cause, nonfatal acute coronary syndrome (ACS), nonfatal stroke, and CAD) for a 3-year follow-up period. Patients were divided into 4 groups based on serum TG level: low-normal (<100 mg/dL), high-normal (100-149 mg/dL), borderline hypertriglyceridemia (150-199 mg/dL), and moderate hypertriglyceridemia (≥200 mg/dL). During a median follow-up period of 46.6 months, 14 patients died (9 from CV causes), 16 had nonfatal ACS, 6 had nonfatal stroke, and 54 had CAD. The Kaplan-Meier curves for first major CV event among the 4 groups were significantly different (P=0.04). After adjustment for various confounders, serum TG level ≥100 mg/dL were significantly associated with an increased risk of first major CV events compared with serum TG level <100 mg/dL. Conclusions: Serum TG level may be a surrogate marker for predicting CV events in patients with CAD.",
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T1 - Target of triglycerides as residual risk for cardiovascular events in patients with coronary artery disease

T2 - Post hoc analysis of the FMD-J study A

AU - Kajikawa, Masato

AU - Maruhashi, Tatsuya

AU - Kishimoto, Shinji

AU - Matsui, Shogo

AU - Hashimoto, Haruki

AU - Takaeko, Yuji

AU - Yusoff, Farina Mohamad

AU - Kihara, Yasuki

AU - Chayama, Kazuaki

AU - Goto, Chikara

AU - Noma, Kensuke

AU - Nakashima, Ayumu

AU - Tomiyama, Hirofumi

AU - Takase, Bonpei

AU - Kohro, Takahide

AU - Suzuki, Toru

AU - Ishizu, Tomoko

AU - Ueda, Shinichiro

AU - Yamazaki, Tsutomu

AU - Furumoto, Tomoo

AU - Kario, Kazuomi

AU - Inoue, Teruo

AU - Koba, Shinji

AU - Watanabe, Kentaro

AU - Takemoto, Yasuhiko

AU - Hano, Takuzo

AU - Sata, Masataka

AU - Ishibashi, Yutaka

AU - Node, Koichi

AU - Maemura, Koji

AU - Ohya, Yusuke

AU - Furukawa, Taiji

AU - Itoh, Hiroshi

AU - Ikeda, Hisao

AU - Yamashina, Akira

AU - Higashi, Yukihito

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Circulating triglyceride (TG) levels are a current focus as a residual risk for cardiovascular (CV) events. We evaluated the relationship between circulating TG levels and future CV events in patients with coronary artery disease (CAD) who were treated with conventional therapy. Methods and Results: We analyzed data for 652 patients who were enrolled in the FMD-J Study A. We investigated the associations between serum TG levels and first major CV events (death from CV cause, nonfatal acute coronary syndrome (ACS), nonfatal stroke, and CAD) for a 3-year follow-up period. Patients were divided into 4 groups based on serum TG level: low-normal (<100 mg/dL), high-normal (100-149 mg/dL), borderline hypertriglyceridemia (150-199 mg/dL), and moderate hypertriglyceridemia (≥200 mg/dL). During a median follow-up period of 46.6 months, 14 patients died (9 from CV causes), 16 had nonfatal ACS, 6 had nonfatal stroke, and 54 had CAD. The Kaplan-Meier curves for first major CV event among the 4 groups were significantly different (P=0.04). After adjustment for various confounders, serum TG level ≥100 mg/dL were significantly associated with an increased risk of first major CV events compared with serum TG level <100 mg/dL. Conclusions: Serum TG level may be a surrogate marker for predicting CV events in patients with CAD.

AB - Background: Circulating triglyceride (TG) levels are a current focus as a residual risk for cardiovascular (CV) events. We evaluated the relationship between circulating TG levels and future CV events in patients with coronary artery disease (CAD) who were treated with conventional therapy. Methods and Results: We analyzed data for 652 patients who were enrolled in the FMD-J Study A. We investigated the associations between serum TG levels and first major CV events (death from CV cause, nonfatal acute coronary syndrome (ACS), nonfatal stroke, and CAD) for a 3-year follow-up period. Patients were divided into 4 groups based on serum TG level: low-normal (<100 mg/dL), high-normal (100-149 mg/dL), borderline hypertriglyceridemia (150-199 mg/dL), and moderate hypertriglyceridemia (≥200 mg/dL). During a median follow-up period of 46.6 months, 14 patients died (9 from CV causes), 16 had nonfatal ACS, 6 had nonfatal stroke, and 54 had CAD. The Kaplan-Meier curves for first major CV event among the 4 groups were significantly different (P=0.04). After adjustment for various confounders, serum TG level ≥100 mg/dL were significantly associated with an increased risk of first major CV events compared with serum TG level <100 mg/dL. Conclusions: Serum TG level may be a surrogate marker for predicting CV events in patients with CAD.

KW - Atherosclerosis

KW - Cardiovascular events

KW - Triglycerides

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