Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells

Herbert Kolodziej; Anne Burmeister; Weronika Trun; Oliver A. Radtke; Albrecht F. Kiderlen; Hideyuki Ito; Tsutomu Hatano; Takashi Yoshida; Yeap Foo Lai

doi:10.1016/j.bmc.2005.07.012

Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells

Herbert Kolodziej, Anne Burmeister, Weronika Trun, Oliver A. Radtke, Albrecht F. Kiderlen, Hideyuki Ito, Tsutomu Hatano, Takashi Yoshida, Yeap Foo Lai

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Some polyphenol-containing extracts (Pelargonium sidoides, Phyllanthus amarus) and representatives of simple phenols (shikimic acid 3- and 5-O-gallate), flavan-3-ols (epigallocatechin 3-gallate), proanthocyanidins (a hexamer) and hydrolysable tannins (corilagin, casuariin, geraniin) were studied for gene expressions (iNOS, IL-1, IL-10, IL-12, IL-18, TNF-α, IFN-α/γ) by RT-PCR. All extracts and compounds were capable of enhancing the iNOS and cytokine mRNA levels in parasitised cells when compared with those in non-infected conditions.

Original language	English
Pages (from-to)	6470-6476
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry
Volume	13
Issue number	23
DOIs	https://doi.org/10.1016/j.bmc.2005.07.012
Publication status	Published - Dec 1 2005
Externally published	Yes

Keywords

Cytokines
Gene expression analysis
Hydrolysable tannins
Inducible nitric oxide synthase
Leishmania major
Macrophages
Polyphenols
Proanthocyanidins

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2005.07.012

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Kolodziej, H., Burmeister, A., Trun, W., Radtke, O. A., Kiderlen, A. F., Ito, H., Hatano, T., Yoshida, T., & Lai, Y. F. (2005). Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells. Bioorganic and Medicinal Chemistry, 13(23), 6470-6476. https://doi.org/10.1016/j.bmc.2005.07.012

Kolodziej, H, Burmeister, A, Trun, W, Radtke, OA, Kiderlen, AF, Ito, H, Hatano, T, Yoshida, T & Lai, YF 2005, 'Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells', Bioorganic and Medicinal Chemistry, vol. 13, no. 23, pp. 6470-6476. https://doi.org/10.1016/j.bmc.2005.07.012

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abstract = "Some polyphenol-containing extracts (Pelargonium sidoides, Phyllanthus amarus) and representatives of simple phenols (shikimic acid 3- and 5-O-gallate), flavan-3-ols (epigallocatechin 3-gallate), proanthocyanidins (a hexamer) and hydrolysable tannins (corilagin, casuariin, geraniin) were studied for gene expressions (iNOS, IL-1, IL-10, IL-12, IL-18, TNF-α, IFN-α/γ) by RT-PCR. All extracts and compounds were capable of enhancing the iNOS and cytokine mRNA levels in parasitised cells when compared with those in non-infected conditions.",

keywords = "Cytokines, Gene expression analysis, Hydrolysable tannins, Inducible nitric oxide synthase, Leishmania major, Macrophages, Polyphenols, Proanthocyanidins",

author = "Herbert Kolodziej and Anne Burmeister and Weronika Trun and Radtke, {Oliver A.} and Kiderlen, {Albrecht F.} and Hideyuki Ito and Tsutomu Hatano and Takashi Yoshida and Lai, {Yeap Foo}",

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doi = "10.1016/j.bmc.2005.07.012",

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AU - Kolodziej, Herbert

AU - Burmeister, Anne

AU - Trun, Weronika

AU - Radtke, Oliver A.

AU - Kiderlen, Albrecht F.

AU - Ito, Hideyuki

AU - Hatano, Tsutomu

AU - Yoshida, Takashi

AU - Lai, Yeap Foo

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KW - Cytokines

KW - Gene expression analysis

KW - Hydrolysable tannins

KW - Inducible nitric oxide synthase

KW - Leishmania major

KW - Macrophages

KW - Polyphenols

KW - Proanthocyanidins

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ER -

Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells

Abstract

Keywords

ASJC Scopus subject areas

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