Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells

Herbert Kolodziej, Anne Burmeister, Weronika Trun, Oliver A. Radtke, Albrecht F. Kiderlen, Hideyuki Ito, Tsutomu Hatano, Takashi Yoshida, Yeap Foo Lai

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Some polyphenol-containing extracts (Pelargonium sidoides, Phyllanthus amarus) and representatives of simple phenols (shikimic acid 3- and 5-O-gallate), flavan-3-ols (epigallocatechin 3-gallate), proanthocyanidins (a hexamer) and hydrolysable tannins (corilagin, casuariin, geraniin) were studied for gene expressions (iNOS, IL-1, IL-10, IL-12, IL-18, TNF-α, IFN-α/γ) by RT-PCR. All extracts and compounds were capable of enhancing the iNOS and cytokine mRNA levels in parasitised cells when compared with those in non-infected conditions.

Original languageEnglish
Pages (from-to)6470-6476
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume13
Issue number23
DOIs
Publication statusPublished - Dec 1 2005

Keywords

  • Cytokines
  • Gene expression analysis
  • Hydrolysable tannins
  • Inducible nitric oxide synthase
  • Leishmania major
  • Macrophages
  • Polyphenols
  • Proanthocyanidins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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