Abstract
Self-assembled surfactant aggregates, such as micelles and vesicles, have been investigated for their application as drug carriers in the treatment of various diseases. However, the characteristics that decide which aggregate is the best drug carrier for each disease have not yet been clarified. In order to design an optimal drug carrier for each disease, various kinds of self-assembled aggregates, such as spherical micelles, lens-like vesicles, and tube-like vesicles, were evaluated by “multiple techniques” including dynamic light scattering, differential scanning calorimetry, nuclear magnetic resonance spectroscopy, and fluorescence measurement using the Laurdan probe. These studies led to the compilation of a database on the formation-dependent properties of self-assembled aggregates. As the relationship between physicochemical properties of self-assembled aggregates and their functions as drug carriers have been extensively reported, this database can be utilized for designing an optimal drug carrier, i.e., a tailor-made drug carrier.
| Original language | English |
|---|---|
| Pages (from-to) | 269-276 |
| Number of pages | 8 |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Volume | 152 |
| DOIs | |
| Publication status | Published - Apr 1 2017 |
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Keywords
- Micelle
- Self-assembly
- Tailor-made drug carrier
- Vesicle
ASJC Scopus subject areas
- Biotechnology
- Surfaces and Interfaces
- Physical and Theoretical Chemistry
- Colloid and Surface Chemistry
Cite this
Tailor-made drug carrier : Comparison of formation-dependent physicochemical properties within self-assembled aggregates for an optimal drug carrier. / Hayashi, Keita; Iwai, Hideka; Kamei, Toshiyuki; Iwamoto, Kaede; Shimanouchi, Toshinori; Fujita, Sakiko; Nakamura, Hidemi; Umakoshi, Hiroshi.
In: Colloids and Surfaces B: Biointerfaces, Vol. 152, 01.04.2017, p. 269-276.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tailor-made drug carrier
T2 - Comparison of formation-dependent physicochemical properties within self-assembled aggregates for an optimal drug carrier
AU - Hayashi, Keita
AU - Iwai, Hideka
AU - Kamei, Toshiyuki
AU - Iwamoto, Kaede
AU - Shimanouchi, Toshinori
AU - Fujita, Sakiko
AU - Nakamura, Hidemi
AU - Umakoshi, Hiroshi
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Self-assembled surfactant aggregates, such as micelles and vesicles, have been investigated for their application as drug carriers in the treatment of various diseases. However, the characteristics that decide which aggregate is the best drug carrier for each disease have not yet been clarified. In order to design an optimal drug carrier for each disease, various kinds of self-assembled aggregates, such as spherical micelles, lens-like vesicles, and tube-like vesicles, were evaluated by “multiple techniques” including dynamic light scattering, differential scanning calorimetry, nuclear magnetic resonance spectroscopy, and fluorescence measurement using the Laurdan probe. These studies led to the compilation of a database on the formation-dependent properties of self-assembled aggregates. As the relationship between physicochemical properties of self-assembled aggregates and their functions as drug carriers have been extensively reported, this database can be utilized for designing an optimal drug carrier, i.e., a tailor-made drug carrier.
AB - Self-assembled surfactant aggregates, such as micelles and vesicles, have been investigated for their application as drug carriers in the treatment of various diseases. However, the characteristics that decide which aggregate is the best drug carrier for each disease have not yet been clarified. In order to design an optimal drug carrier for each disease, various kinds of self-assembled aggregates, such as spherical micelles, lens-like vesicles, and tube-like vesicles, were evaluated by “multiple techniques” including dynamic light scattering, differential scanning calorimetry, nuclear magnetic resonance spectroscopy, and fluorescence measurement using the Laurdan probe. These studies led to the compilation of a database on the formation-dependent properties of self-assembled aggregates. As the relationship between physicochemical properties of self-assembled aggregates and their functions as drug carriers have been extensively reported, this database can be utilized for designing an optimal drug carrier, i.e., a tailor-made drug carrier.
KW - Micelle
KW - Self-assembly
KW - Tailor-made drug carrier
KW - Vesicle
UR - http://www.scopus.com/inward/record.url?scp=85009863149&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009863149&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2017.01.012
DO - 10.1016/j.colsurfb.2017.01.012
M3 - Article
C2 - 28119222
AN - SCOPUS:85009863149
VL - 152
SP - 269
EP - 276
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
SN - 0927-7765
ER -