t(8;14)(q24;q32) in two patients with CD10-negative primary thyroid diffuse large B-cell lymphoma

Nozomi Niitsu, Masataka Okamoto, Tadashi Yoshino, Hirokazu Nakamine, Naoya Nakamura, Masami Bessho, Masami Hirano, Ikuo Miura

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4 Citations (Scopus)

Abstract

Diffuse large B-cell lymphoma (DLBCL) with the 8q24 translocation is occasionally seen in the gastrointestinal tract, but has rarely been reported in the thyroid gland. We experienced two cases of primary thyroid DLBCL having t(8;14)(q24;q32). The immunophenotype and karyotype of Case 1 (66-year-old female) and Case 2 (70-year-old female) were: CD10-, CD20+, BCL-2+/add(13)(q34), t(8;14)(q24;q32) and CD10-, CD20-, CD79a+, BCL-2-/t(8;14)(q24;q32), respectively. Although long-term complete remission could be achieved in both of our patients by conventional chemotherapy with/without radiation therapy, accumulation of further such cases is necessary to develop a standard treatment protocol and also to elucidate the pathogenesis of t(8;14)(q24;q32)-positive primary thyroid DLBCL.

Original languageEnglish
Pages (from-to)707-711
Number of pages5
JournalLeukemia Research
Volume31
Issue number5
DOIs
Publication statusPublished - May 2007
Externally publishedYes

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Keywords

  • c-MYC
  • Diffuse large B-cell lymphoma
  • t(8 ;14)(q24 ;q32)
  • Thyroid

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Niitsu, N., Okamoto, M., Yoshino, T., Nakamine, H., Nakamura, N., Bessho, M., Hirano, M., & Miura, I. (2007). t(8;14)(q24;q32) in two patients with CD10-negative primary thyroid diffuse large B-cell lymphoma. Leukemia Research, 31(5), 707-711. https://doi.org/10.1016/j.leukres.2006.06.014