T cell growth factors from adult T cell leukemia virus-transformed cell lines

Yasuji Okai, Takashi Oka, Tadaatsu Akagi, Sayuri Kurata, Nobuo Fujiyoshi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Some characteristics of T cell growth factors derived from adult T cell leukemia virus (ATLV)-transformed cell lines, MT 1 and MT 2 were analyzed. MT 1 cells release significant interleukin 2 (IL 2) activity into the culture medium, which showed the same elution pattern of gel filtration and isoelectric focusing of IL 2 from lectin-stimulated normal human lymphocytes. This activity was also detected in the cell extract of MT 1. In contrast, MT 2 cell line did not produce IL 2 activity, but non-IL 2 type growth factor was observed. The significance of these factors from MT cell lines is discussed from the viewpoint of 'autokine' in ATLV-transformed cells. ALTV-transformed cell T cell growth factor.

Original languageEnglish
Pages (from-to)200-204
Number of pages5
JournalFEBS Letters
Volume177
Issue number2
DOIs
Publication statusPublished - Nov 19 1984
Externally publishedYes

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Adult T Cell Leukemia Lymphoma
Transformed Cell Line
T-cells
Viruses
Interleukin-2
Cells
Cell Line
Lymphocytes
Isoelectric Focusing
Cell Extracts
Lectins
Gel Chromatography
Culture Media
Intercellular Signaling Peptides and Proteins
Gels

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

T cell growth factors from adult T cell leukemia virus-transformed cell lines. / Okai, Yasuji; Oka, Takashi; Akagi, Tadaatsu; Kurata, Sayuri; Fujiyoshi, Nobuo.

In: FEBS Letters, Vol. 177, No. 2, 19.11.1984, p. 200-204.

Research output: Contribution to journalArticle

Okai, Yasuji ; Oka, Takashi ; Akagi, Tadaatsu ; Kurata, Sayuri ; Fujiyoshi, Nobuo. / T cell growth factors from adult T cell leukemia virus-transformed cell lines. In: FEBS Letters. 1984 ; Vol. 177, No. 2. pp. 200-204.
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