T cell growth factors from adult T cell leukemia virus-transformed cell lines

Yasuji Okai, Takashi Oka, Tadaatsu Akagi, Sayuri Kurata, Nobuo Fujiyoshi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Some characteristics of T cell growth factors derived from adult T cell leukemia virus (ATLV)-transformed cell lines, MT 1 and MT 2 were analyzed. MT 1 cells release significant interleukin 2 (IL 2) activity into the culture medium, which showed the same elution pattern of gel filtration and isoelectric focusing of IL 2 from lectin-stimulated normal human lymphocytes. This activity was also detected in the cell extract of MT 1. In contrast, MT 2 cell line did not produce IL 2 activity, but non-IL 2 type growth factor was observed. The significance of these factors from MT cell lines is discussed from the viewpoint of 'autokine' in ATLV-transformed cells. ALTV-transformed cell T cell growth factor.

Original languageEnglish
Pages (from-to)200-204
Number of pages5
JournalFEBS Letters
Volume177
Issue number2
DOIs
Publication statusPublished - Nov 19 1984
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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