Systemic inflammatory response syndrome and acute renal failure associated with Hemophilus influenzae septic meningitis

Mitsutoshi Nishimura, Hirokazu Tsukahara, Masahiro Hiraoka, Yoko Osaka, Yusei Ohshima, Akihiko Tanizawa, Mitsufumi Mayumi

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6 Citations (Scopus)


Sepsis is often associated with a downward spiral through a spectrum of systemic inflammatory response syndrome (SIRS) culminating in organ failure and death. Here we present a 3-year-old girl with Hemophilus influenzae septic meningitis who developed SIRS and acute renal failure. In the initial stage, the patient showed uremia, cytopenia, disseminated intravascular coagulation, elevation of tissue enzyme and ferritin values, hemophagocytosis and overproduction of nitric oxide. The serum cytokine profile revealed increased levels of soluble interleukin (IL)-2 receptor, IL-6, IL-10 and tumor necrosis factor α. The patient responded positively to early and intensive interventions including antibiotics, repeated exchange transfusions, dexamethasone and high-dose γ-globulin. The above laboratory abnormalities almost normalized with clinical improvement. We consider that SIRS was probably responsible for the sequence of events resulting in renal failure in this case, and suggest that renal failure should be included among the serious complications of SIRS associated with Hemophilus influenzae septic meningitis. (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)208-211
Number of pages4
JournalAmerican Journal of Nephrology
Issue number3
Publication statusPublished - Jan 1 2000
Externally publishedYes



  • Acute renal failure
  • Cytokine
  • Hemophilus influenzae
  • Septic meningitis
  • Systemic inflammatory response syndrome

ASJC Scopus subject areas

  • Nephrology

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