TY - JOUR
T1 - Systemic inflammatory response syndrome and acute renal failure associated with Hemophilus influenzae septic meningitis
AU - Nishimura, Mitsutoshi
AU - Tsukahara, Hirokazu
AU - Hiraoka, Masahiro
AU - Osaka, Yoko
AU - Ohshima, Yusei
AU - Tanizawa, Akihiko
AU - Mayumi, Mitsufumi
PY - 2000
Y1 - 2000
N2 - Sepsis is often associated with a downward spiral through a spectrum of systemic inflammatory response syndrome (SIRS) culminating in organ failure and death. Here we present a 3-year-old girl with Hemophilus influenzae septic meningitis who developed SIRS and acute renal failure. In the initial stage, the patient showed uremia, cytopenia, disseminated intravascular coagulation, elevation of tissue enzyme and ferritin values, hemophagocytosis and overproduction of nitric oxide. The serum cytokine profile revealed increased levels of soluble interleukin (IL)-2 receptor, IL-6, IL-10 and tumor necrosis factor α. The patient responded positively to early and intensive interventions including antibiotics, repeated exchange transfusions, dexamethasone and high-dose γ-globulin. The above laboratory abnormalities almost normalized with clinical improvement. We consider that SIRS was probably responsible for the sequence of events resulting in renal failure in this case, and suggest that renal failure should be included among the serious complications of SIRS associated with Hemophilus influenzae septic meningitis. (C) 2000 S. Karger AG, Basel.
AB - Sepsis is often associated with a downward spiral through a spectrum of systemic inflammatory response syndrome (SIRS) culminating in organ failure and death. Here we present a 3-year-old girl with Hemophilus influenzae septic meningitis who developed SIRS and acute renal failure. In the initial stage, the patient showed uremia, cytopenia, disseminated intravascular coagulation, elevation of tissue enzyme and ferritin values, hemophagocytosis and overproduction of nitric oxide. The serum cytokine profile revealed increased levels of soluble interleukin (IL)-2 receptor, IL-6, IL-10 and tumor necrosis factor α. The patient responded positively to early and intensive interventions including antibiotics, repeated exchange transfusions, dexamethasone and high-dose γ-globulin. The above laboratory abnormalities almost normalized with clinical improvement. We consider that SIRS was probably responsible for the sequence of events resulting in renal failure in this case, and suggest that renal failure should be included among the serious complications of SIRS associated with Hemophilus influenzae septic meningitis. (C) 2000 S. Karger AG, Basel.
KW - Acute renal failure
KW - Cytokine
KW - Hemophilus influenzae
KW - Septic meningitis
KW - Systemic inflammatory response syndrome
UR - http://www.scopus.com/inward/record.url?scp=0033944983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033944983&partnerID=8YFLogxK
U2 - 10.1159/000013585
DO - 10.1159/000013585
M3 - Article
C2 - 10878402
AN - SCOPUS:0033944983
VL - 20
SP - 208
EP - 211
JO - American Journal of Nephrology
JF - American Journal of Nephrology
SN - 0250-8095
IS - 3
ER -