Abstract
Purpose : To report a case of lymphoma metastatic to the eye and central nervous system that responded to high-dosis methotrexate. Case and Findings : A 71-year-old woman noted blurring of vision in the left eye since 5 months before. She had had diffuse large B cell lymphoma in the neck region that regressed after chemotherapy 18 months before. Her corrected visual acuity was 0.5 right and hand motion left. Both eyes showed exudative patches in the retina. Biopsy of opaque vitreous in the left eye led to the diagnosis of malignant B-cell lymphoma. One month after successful radiation to the left eye, visual acuity in the right eye decreased to 0.07 due to vitreous opacity associated by intracranial metastasis. High-dosis methotrexate resulted in remission of intraocular and intracranial lesions with right visual acuity of 0.4 7 months later. Conclusion : Systemic high-dosis methotrexate was effective for malignant lymphoma systemic to the eye and central nervous system.
| Original language | English |
|---|---|
| Pages (from-to) | 337-340 |
| Number of pages | 4 |
| Journal | Japanese Journal of Clinical Ophthalmology |
| Volume | 63 |
| Issue number | 3 |
| Publication status | Published - Apr 7 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Systemic high-dosis methotrexate was effective in a case of metastatic intraocular lymphoma. / Hosokawa, Mio; Terada, Yoshiko; Yamane, Takashi; Hara, Kazuyuki; Terada, Kinya; Sasaki, Tatsuya; Noda, Masaaki.
In: Japanese Journal of Clinical Ophthalmology, Vol. 63, No. 3, 07.04.2009, p. 337-340.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Systemic high-dosis methotrexate was effective in a case of metastatic intraocular lymphoma
AU - Hosokawa, Mio
AU - Terada, Yoshiko
AU - Yamane, Takashi
AU - Hara, Kazuyuki
AU - Terada, Kinya
AU - Sasaki, Tatsuya
AU - Noda, Masaaki
PY - 2009/4/7
Y1 - 2009/4/7
N2 - Purpose : To report a case of lymphoma metastatic to the eye and central nervous system that responded to high-dosis methotrexate. Case and Findings : A 71-year-old woman noted blurring of vision in the left eye since 5 months before. She had had diffuse large B cell lymphoma in the neck region that regressed after chemotherapy 18 months before. Her corrected visual acuity was 0.5 right and hand motion left. Both eyes showed exudative patches in the retina. Biopsy of opaque vitreous in the left eye led to the diagnosis of malignant B-cell lymphoma. One month after successful radiation to the left eye, visual acuity in the right eye decreased to 0.07 due to vitreous opacity associated by intracranial metastasis. High-dosis methotrexate resulted in remission of intraocular and intracranial lesions with right visual acuity of 0.4 7 months later. Conclusion : Systemic high-dosis methotrexate was effective for malignant lymphoma systemic to the eye and central nervous system.
AB - Purpose : To report a case of lymphoma metastatic to the eye and central nervous system that responded to high-dosis methotrexate. Case and Findings : A 71-year-old woman noted blurring of vision in the left eye since 5 months before. She had had diffuse large B cell lymphoma in the neck region that regressed after chemotherapy 18 months before. Her corrected visual acuity was 0.5 right and hand motion left. Both eyes showed exudative patches in the retina. Biopsy of opaque vitreous in the left eye led to the diagnosis of malignant B-cell lymphoma. One month after successful radiation to the left eye, visual acuity in the right eye decreased to 0.07 due to vitreous opacity associated by intracranial metastasis. High-dosis methotrexate resulted in remission of intraocular and intracranial lesions with right visual acuity of 0.4 7 months later. Conclusion : Systemic high-dosis methotrexate was effective for malignant lymphoma systemic to the eye and central nervous system.
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M3 - Article
VL - 63
SP - 337
EP - 340
JO - Japanese Journal of Clinical Ophthalmology
JF - Japanese Journal of Clinical Ophthalmology
SN - 0370-5579
IS - 3
ER -