Systemic high-dosis methotrexate was effective in a case of metastatic intraocular lymphoma

Mio Hosokawa, Yoshiko Terada, Takashi Yamane, Kazuyuki Hara, Kinya Terada, Tatsuya Sasaki, Masaaki Noda

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Abstract

Purpose : To report a case of lymphoma metastatic to the eye and central nervous system that responded to high-dosis methotrexate. Case and Findings : A 71-year-old woman noted blurring of vision in the left eye since 5 months before. She had had diffuse large B cell lymphoma in the neck region that regressed after chemotherapy 18 months before. Her corrected visual acuity was 0.5 right and hand motion left. Both eyes showed exudative patches in the retina. Biopsy of opaque vitreous in the left eye led to the diagnosis of malignant B-cell lymphoma. One month after successful radiation to the left eye, visual acuity in the right eye decreased to 0.07 due to vitreous opacity associated by intracranial metastasis. High-dosis methotrexate resulted in remission of intraocular and intracranial lesions with right visual acuity of 0.4 7 months later. Conclusion : Systemic high-dosis methotrexate was effective for malignant lymphoma systemic to the eye and central nervous system.

Original languageEnglish
Pages (from-to)337-340
Number of pages4
JournalJapanese Journal of Clinical Ophthalmology
Volume63
Issue number3
Publication statusPublished - Apr 7 2009
Externally publishedYes

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ASJC Scopus subject areas

  • Ophthalmology

Cite this

Hosokawa, M., Terada, Y., Yamane, T., Hara, K., Terada, K., Sasaki, T., & Noda, M. (2009). Systemic high-dosis methotrexate was effective in a case of metastatic intraocular lymphoma. Japanese Journal of Clinical Ophthalmology, 63(3), 337-340.