Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma

Kazuto Togitani; Tadashi Asagiri; Mitsuko Iguchi; Takuro Igawa; Tadashi Yoshino; Kensuke Kojima

doi:10.2169/internalmedicine.8968-21

Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma

Kazuto Togitani, Tadashi Asagiri, Mitsuko Iguchi, Takuro Igawa, Tadashi Yoshino, Kensuke Kojima

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A 52-year-old man presented with palatine tonsillar swelling caused by follicular lymphoma. His tumor burden was low, but exacerbation of snoring and dysphagia was observed. Considering the first wave of coronavirus disease 2019 (COVID-19) pandemic, he received palliative 4-Gy irradiation to the tonsils in 2 fractions, which induced partial regression of tonsillar swellings and eradication of the circulating lymphoma cells. We suggest that low-dose radiotherapy triggered an abscopal effect of lymphoma, which allowed the patient time to receive COVID-19 vaccination before starting immunosuppressive chemo-immunotherapy.

Original language	English
Pages (from-to)	3107-3110
Number of pages	4
Journal	Internal Medicine
Volume	61
Issue number	20
DOIs	https://doi.org/10.2169/internalmedicine.8968-21
Publication status	Published - 2022

Keywords

abscopal effect
CD5
follicular lymphoma
low-dose radiotherapy

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2169/internalmedicine.8968-21

Cite this

@article{223e4e3412e14e26bcdc60abbcb5da90,

title = "Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma",

abstract = "A 52-year-old man presented with palatine tonsillar swelling caused by follicular lymphoma. His tumor burden was low, but exacerbation of snoring and dysphagia was observed. Considering the first wave of coronavirus disease 2019 (COVID-19) pandemic, he received palliative 4-Gy irradiation to the tonsils in 2 fractions, which induced partial regression of tonsillar swellings and eradication of the circulating lymphoma cells. We suggest that low-dose radiotherapy triggered an abscopal effect of lymphoma, which allowed the patient time to receive COVID-19 vaccination before starting immunosuppressive chemo-immunotherapy.",

keywords = "abscopal effect, CD5, follicular lymphoma, low-dose radiotherapy",

author = "Kazuto Togitani and Tadashi Asagiri and Mitsuko Iguchi and Takuro Igawa and Tadashi Yoshino and Kensuke Kojima",

year = "2022",

doi = "10.2169/internalmedicine.8968-21",

language = "English",

volume = "61",

pages = "3107--3110",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "20",

}

TY - JOUR

T1 - Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma

AU - Togitani, Kazuto

AU - Asagiri, Tadashi

AU - Iguchi, Mitsuko

AU - Igawa, Takuro

AU - Yoshino, Tadashi

AU - Kojima, Kensuke

PY - 2022

Y1 - 2022

N2 - A 52-year-old man presented with palatine tonsillar swelling caused by follicular lymphoma. His tumor burden was low, but exacerbation of snoring and dysphagia was observed. Considering the first wave of coronavirus disease 2019 (COVID-19) pandemic, he received palliative 4-Gy irradiation to the tonsils in 2 fractions, which induced partial regression of tonsillar swellings and eradication of the circulating lymphoma cells. We suggest that low-dose radiotherapy triggered an abscopal effect of lymphoma, which allowed the patient time to receive COVID-19 vaccination before starting immunosuppressive chemo-immunotherapy.

AB - A 52-year-old man presented with palatine tonsillar swelling caused by follicular lymphoma. His tumor burden was low, but exacerbation of snoring and dysphagia was observed. Considering the first wave of coronavirus disease 2019 (COVID-19) pandemic, he received palliative 4-Gy irradiation to the tonsils in 2 fractions, which induced partial regression of tonsillar swellings and eradication of the circulating lymphoma cells. We suggest that low-dose radiotherapy triggered an abscopal effect of lymphoma, which allowed the patient time to receive COVID-19 vaccination before starting immunosuppressive chemo-immunotherapy.

KW - abscopal effect

KW - CD5

KW - follicular lymphoma

KW - low-dose radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=85140143883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85140143883&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.8968-21

DO - 10.2169/internalmedicine.8968-21

M3 - Article

C2 - 35314548

AN - SCOPUS:85140143883

SN - 0918-2918

VL - 61

SP - 3107

EP - 3110

JO - Internal Medicine

JF - Internal Medicine

IS - 20

ER -

Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this