Systematic review and meta-analysis for 2017 clinical practice guidelines of the Japan research committee of the ministry of health, labour, and welfare for intractable vasculitis for the management of ANCA-associated vasculitis

Kenji Nagasaka, Masayoshi Harigai, Noboru Hagino, Akinori Hara, Tetsuya Horita, Taichi Hayashi, Mitsuyo Itabashi, Satoshi Ito, Yasuhiro Katsumata, Soko Kawashima, Taio Naniwa, Kenei Sada, Eishu Nango, Takeo Nakayama, Michi Tsutsumino, Kunihiro Yamagata, Sakae Homma, Yoshihiro Arimura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: To provide evidence for the revision of clinical practice guideline (CPG) for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the Japan Research Committee for Intractable Vasculitis. Methods: PubMed, CENTRAL, and the Japan Medical Abstracts Society were searched for articles published between January 1994 and January 2015 to conduct systematic review (SR), and the quality of evidence was assessed with GRADE approach. Results: Nine randomized controlled trials (RCTs) and two non-RCTs were adopted for remission induction therapy, three RCTs and two non-RCTs for plasma exchange, and five RCTs and one non-RCT for remission maintenance therapy. A significant difference was found in efficacy and safety for the following comparisons. In the non-RCT adopted for remission induction therapy, glucocorticoid (GC) + cyclophosphamide (CY) was significantly superior to GC monotherapy regarding remission. GC + intravenous CY for remission induction therapy was superior to GC + oral CY regarding death at one year, serious adverse events, and serious infection. Concomitant use of plasma exchange for remission induction therapy of AAV with severe renal dysfunction reduced risk of end-stage renal disease versus non-users at month 3. Conclusion: This SR provided necessary evidence for developing CPG for the management of ANCA-associated vasculitis.

Original languageEnglish
JournalModern Rheumatology
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Antineutrophil Cytoplasmic Antibodies
Remission Induction
Vasculitis
Practice Guidelines
Meta-Analysis
Japan
Glucocorticoids
Cyclophosphamide
Health
Research
Plasma Exchange
Randomized Controlled Trials
Practice Management
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Therapeutics
Medical Societies
PubMed
Chronic Kidney Failure
Kidney
Safety

Keywords

  • ANCA-associated vasculitis
  • GRADE system
  • granulomatosis with polyangiitis
  • microscopic polyangiitis
  • systematic review

ASJC Scopus subject areas

  • Rheumatology

Cite this

Systematic review and meta-analysis for 2017 clinical practice guidelines of the Japan research committee of the ministry of health, labour, and welfare for intractable vasculitis for the management of ANCA-associated vasculitis. / Nagasaka, Kenji; Harigai, Masayoshi; Hagino, Noboru; Hara, Akinori; Horita, Tetsuya; Hayashi, Taichi; Itabashi, Mitsuyo; Ito, Satoshi; Katsumata, Yasuhiro; Kawashima, Soko; Naniwa, Taio; Sada, Kenei; Nango, Eishu; Nakayama, Takeo; Tsutsumino, Michi; Yamagata, Kunihiro; Homma, Sakae; Arimura, Yoshihiro.

In: Modern Rheumatology, 01.01.2018.

Research output: Contribution to journalArticle

Nagasaka, K, Harigai, M, Hagino, N, Hara, A, Horita, T, Hayashi, T, Itabashi, M, Ito, S, Katsumata, Y, Kawashima, S, Naniwa, T, Sada, K, Nango, E, Nakayama, T, Tsutsumino, M, Yamagata, K, Homma, S & Arimura, Y 2018, 'Systematic review and meta-analysis for 2017 clinical practice guidelines of the Japan research committee of the ministry of health, labour, and welfare for intractable vasculitis for the management of ANCA-associated vasculitis', Modern Rheumatology. https://doi.org/10.1080/14397595.2018.1500111
Nagasaka, Kenji ; Harigai, Masayoshi ; Hagino, Noboru ; Hara, Akinori ; Horita, Tetsuya ; Hayashi, Taichi ; Itabashi, Mitsuyo ; Ito, Satoshi ; Katsumata, Yasuhiro ; Kawashima, Soko ; Naniwa, Taio ; Sada, Kenei ; Nango, Eishu ; Nakayama, Takeo ; Tsutsumino, Michi ; Yamagata, Kunihiro ; Homma, Sakae ; Arimura, Yoshihiro. / Systematic review and meta-analysis for 2017 clinical practice guidelines of the Japan research committee of the ministry of health, labour, and welfare for intractable vasculitis for the management of ANCA-associated vasculitis. In: Modern Rheumatology. 2018.
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abstract = "Objectives: To provide evidence for the revision of clinical practice guideline (CPG) for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the Japan Research Committee for Intractable Vasculitis. Methods: PubMed, CENTRAL, and the Japan Medical Abstracts Society were searched for articles published between January 1994 and January 2015 to conduct systematic review (SR), and the quality of evidence was assessed with GRADE approach. Results: Nine randomized controlled trials (RCTs) and two non-RCTs were adopted for remission induction therapy, three RCTs and two non-RCTs for plasma exchange, and five RCTs and one non-RCT for remission maintenance therapy. A significant difference was found in efficacy and safety for the following comparisons. In the non-RCT adopted for remission induction therapy, glucocorticoid (GC) + cyclophosphamide (CY) was significantly superior to GC monotherapy regarding remission. GC + intravenous CY for remission induction therapy was superior to GC + oral CY regarding death at one year, serious adverse events, and serious infection. Concomitant use of plasma exchange for remission induction therapy of AAV with severe renal dysfunction reduced risk of end-stage renal disease versus non-users at month 3. Conclusion: This SR provided necessary evidence for developing CPG for the management of ANCA-associated vasculitis.",
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AU - Harigai, Masayoshi

AU - Hagino, Noboru

AU - Hara, Akinori

AU - Horita, Tetsuya

AU - Hayashi, Taichi

AU - Itabashi, Mitsuyo

AU - Ito, Satoshi

AU - Katsumata, Yasuhiro

AU - Kawashima, Soko

AU - Naniwa, Taio

AU - Sada, Kenei

AU - Nango, Eishu

AU - Nakayama, Takeo

AU - Tsutsumino, Michi

AU - Yamagata, Kunihiro

AU - Homma, Sakae

AU - Arimura, Yoshihiro

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