Abstract
Interleukin (IL)-6 is a proinflammatory cytokine that performs a wide variety of biological functions, including important roles in the progression of chronic inflammatory diseases such as periodontal disease. (+)-Terrein, a secondary bioactive fungal metabolite isolated from Aspergillus terreus, has various biological activities; however, its anti-inflammatory effects are still unknown. The purpose of this study was to examine the effect of synthetic (+)-terrein on IL-6 signaling and related protein production in human gingival fibroblasts. To our knowledge, this study is the first to report that synthetic (+)-terrein is not cytotoxic at concentrations less than 20 μM and suppresses IL-6/soluble IL-6 receptor (sIL-6R)-induced phosphorylation of signal transducer and activator of transcription-3, extracellular signal-regulated kinase 1/2, and c-jun N-terminal kinase 1/2 - signaling proteins that are downstream of IL-6 signaling. In addition, synthetic (+)-terrein suppresses IL-6/sIL-6R-induced vascular endothelial growth factor (VEGF) secretion in a concentration-dependent manner (p
| Original language | English |
|---|---|
| Pages (from-to) | 5338-5344 |
| Number of pages | 7 |
| Journal | Bioorganic and Medicinal Chemistry |
| Volume | 22 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - Oct 1 2014 |
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Keywords
- (+)-Terrein
- Chronic inflammation
- Human gingival fibroblast
- IL-6
- VEGF
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Molecular Biology
- Molecular Medicine
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
- Medicine(all)
Cite this
Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts. / Mandai, Hiroki; Omori, Kazuhiro; Yamamoto, Daisuke; Tsumura, Toki; Murota, Kyouta; Yamamoto, Satoshi; Mitsudo, Koichi; Ibaragi, Soichiro; Sasaki, Akira; Maeda, Hiroshi; Takashiba, Shogo; Suga, Seiji.
In: Bioorganic and Medicinal Chemistry, Vol. 22, No. 19, 01.10.2014, p. 5338-5344.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts
AU - Mandai, Hiroki
AU - Omori, Kazuhiro
AU - Yamamoto, Daisuke
AU - Tsumura, Toki
AU - Murota, Kyouta
AU - Yamamoto, Satoshi
AU - Mitsudo, Koichi
AU - Ibaragi, Soichiro
AU - Sasaki, Akira
AU - Maeda, Hiroshi
AU - Takashiba, Shogo
AU - Suga, Seiji
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Interleukin (IL)-6 is a proinflammatory cytokine that performs a wide variety of biological functions, including important roles in the progression of chronic inflammatory diseases such as periodontal disease. (+)-Terrein, a secondary bioactive fungal metabolite isolated from Aspergillus terreus, has various biological activities; however, its anti-inflammatory effects are still unknown. The purpose of this study was to examine the effect of synthetic (+)-terrein on IL-6 signaling and related protein production in human gingival fibroblasts. To our knowledge, this study is the first to report that synthetic (+)-terrein is not cytotoxic at concentrations less than 20 μM and suppresses IL-6/soluble IL-6 receptor (sIL-6R)-induced phosphorylation of signal transducer and activator of transcription-3, extracellular signal-regulated kinase 1/2, and c-jun N-terminal kinase 1/2 - signaling proteins that are downstream of IL-6 signaling. In addition, synthetic (+)-terrein suppresses IL-6/sIL-6R-induced vascular endothelial growth factor (VEGF) secretion in a concentration-dependent manner (p
AB - Interleukin (IL)-6 is a proinflammatory cytokine that performs a wide variety of biological functions, including important roles in the progression of chronic inflammatory diseases such as periodontal disease. (+)-Terrein, a secondary bioactive fungal metabolite isolated from Aspergillus terreus, has various biological activities; however, its anti-inflammatory effects are still unknown. The purpose of this study was to examine the effect of synthetic (+)-terrein on IL-6 signaling and related protein production in human gingival fibroblasts. To our knowledge, this study is the first to report that synthetic (+)-terrein is not cytotoxic at concentrations less than 20 μM and suppresses IL-6/soluble IL-6 receptor (sIL-6R)-induced phosphorylation of signal transducer and activator of transcription-3, extracellular signal-regulated kinase 1/2, and c-jun N-terminal kinase 1/2 - signaling proteins that are downstream of IL-6 signaling. In addition, synthetic (+)-terrein suppresses IL-6/sIL-6R-induced vascular endothelial growth factor (VEGF) secretion in a concentration-dependent manner (p
KW - (+)-Terrein
KW - Chronic inflammation
KW - Human gingival fibroblast
KW - IL-6
KW - VEGF
UR - http://www.scopus.com/inward/record.url?scp=84907563473&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907563473&partnerID=8YFLogxK
U2 - 10.1016/j.bmc.2014.07.047
DO - 10.1016/j.bmc.2014.07.047
M3 - Article
C2 - 25151086
AN - SCOPUS:84907563473
VL - 22
SP - 5338
EP - 5344
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
SN - 0968-0896
IS - 19
ER -