Synthetic studies towards gambierol. Part 2: Synthesis of the EFGH ring segment

Isao Kadota, Chie Kadowaki, Hiroyoshi Takamura, Yoshinori Yamamoto

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19 Citations (Scopus)

Abstract

The EFGH ring segment of gambierol was synthesized from 2-deoxy-D-ribose in 40 steps. The present synthesis includes a SmI2-mediated reductive cyclization and a Pd-catalyzed coupling of enol triflate with a zinc bis-homoenolate as key steps.

Original languageEnglish
Pages (from-to)6199-6202
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number35
DOIs
Publication statusPublished - Aug 27 2001

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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