Abstract
The EFGH ring segment of gambierol was synthesized from 2-deoxy-D-ribose in 40 steps. The present synthesis includes a SmI2-mediated reductive cyclization and a Pd-catalyzed coupling of enol triflate with a zinc bis-homoenolate as key steps.
| Original language | English |
|---|---|
| Pages (from-to) | 6199-6202 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 42 |
| Issue number | 35 |
| DOIs | |
| Publication status | Published - Aug 27 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Synthetic studies towards gambierol. Part 2 : Synthesis of the EFGH ring segment. / Kadota, Isao; Kadowaki, Chie; Takamura, Hiroyoshi; Yamamoto, Yoshinori.
In: Tetrahedron Letters, Vol. 42, No. 35, 27.08.2001, p. 6199-6202.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthetic studies towards gambierol. Part 2
T2 - Synthesis of the EFGH ring segment
AU - Kadota, Isao
AU - Kadowaki, Chie
AU - Takamura, Hiroyoshi
AU - Yamamoto, Yoshinori
PY - 2001/8/27
Y1 - 2001/8/27
N2 - The EFGH ring segment of gambierol was synthesized from 2-deoxy-D-ribose in 40 steps. The present synthesis includes a SmI2-mediated reductive cyclization and a Pd-catalyzed coupling of enol triflate with a zinc bis-homoenolate as key steps.
AB - The EFGH ring segment of gambierol was synthesized from 2-deoxy-D-ribose in 40 steps. The present synthesis includes a SmI2-mediated reductive cyclization and a Pd-catalyzed coupling of enol triflate with a zinc bis-homoenolate as key steps.
UR - http://www.scopus.com/inward/record.url?scp=0035959492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035959492&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(01)01205-9
DO - 10.1016/S0040-4039(01)01205-9
M3 - Article
AN - SCOPUS:0035959492
VL - 42
SP - 6199
EP - 6202
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 35
ER -