Synthetic studies towards gambierol. Part 2: Synthesis of the EFGH ring segment

Isao Kadota; Chie Kadowaki; Hiroyoshi Takamura; Yoshinori Yamamoto

doi:10.1016/S0040-4039(01)01205-9

Synthetic studies towards gambierol. Part 2: Synthesis of the EFGH ring segment

Isao Kadota, Chie Kadowaki, Hiroyoshi Takamura, Yoshinori Yamamoto

Research output: Contribution to journal › Article

19 Citations (Scopus)

Abstract

The EFGH ring segment of gambierol was synthesized from 2-deoxy-D-ribose in 40 steps. The present synthesis includes a SmI₂-mediated reductive cyclization and a Pd-catalyzed coupling of enol triflate with a zinc bis-homoenolate as key steps.

Original language	English
Pages (from-to)	6199-6202
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	35
DOIs	https://doi.org/10.1016/S0040-4039(01)01205-9
Publication status	Published - Aug 27 2001

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ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Kadota, I., Kadowaki, C., Takamura, H., & Yamamoto, Y. (2001). Synthetic studies towards gambierol. Part 2: Synthesis of the EFGH ring segment. Tetrahedron Letters, 42(35), 6199-6202. https://doi.org/10.1016/S0040-4039(01)01205-9

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Access to Document

10.1016/S0040-4039(01)01205-9