Synthetic studies toward biselides. Part 1: Synthesis of the core carbon framework of biselides A, B, and e using Stille coupling

Yohsuke Satoh, Dai Kawamura, Masashi Yamaura, Yoichi Ikeda, Yumi Ochiai, Ichiro Hayakawa, Hideo Kigoshi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Biselides A and B are cytotoxic marine polyketides. We have achieved synthesis of the C-1-C-15 segment of biselides A and B by using Stille coupling and regioselective oxidative cleavage as key steps. Furthermore, we constructed the α,β-unsaturated lactone part of biselide E by using a similar strategy.

Original languageEnglish
Pages (from-to)1390-1392
Number of pages3
JournalTetrahedron Letters
Volume53
Issue number11
DOIs
Publication statusPublished - Mar 14 2012
Externally publishedYes

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Keywords

  • Biselides
  • Polyketides
  • Regioselective oxidative cleavage
  • Stille coupling

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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