Abstract
The reaction of bromo-methoxysalicylaldehyde (4-6) and bromo- hydroxysalicylaldehyde (18) with carbethoxymethylenetriphenylphosphorane (2) in diethylaniline under reflux gave unexpected debromocoumarins along with an expected bromocoumarin. The oxygen function might facilitate debromination in the process of coumarin synthesis at an elevated temperature.
Original language | English |
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Pages (from-to) | 765-772 |
Number of pages | 8 |
Journal | Yakugaku Zasshi |
Volume | 115 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1995 |
Keywords
- Wittig reaction
- bromo- methoxycoumarin
- bromo-hydroxycoumarin
- coumarin synthesis
- debromination
- salicylaldehyde
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science