Synthetic studies on bromocoumarins possessing oxygen function

H. Nishioka, N. Hayashida, S. Kawabe, T. Harayama

Research output: Contribution to journalArticlepeer-review


The reaction of bromo-methoxysalicylaldehyde (4-6) and bromo- hydroxysalicylaldehyde (18) with carbethoxymethylenetriphenylphosphorane (2) in diethylaniline under reflux gave unexpected debromocoumarins along with an expected bromocoumarin. The oxygen function might facilitate debromination in the process of coumarin synthesis at an elevated temperature.

Original languageEnglish
Pages (from-to)765-772
Number of pages8
JournalYakugaku Zasshi
Issue number9
Publication statusPublished - 1995


  • Wittig reaction
  • bromo- methoxycoumarin
  • bromo-hydroxycoumarin
  • coumarin synthesis
  • debromination
  • salicylaldehyde

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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