Synthetic studies of enacyloxins: A series of antibiotics isolated from frateuria sp. W-315: C1'-C8' and C9'-C15' Fragments

Aki Saito, Wataru Igarashi, Hiroyuki Furukawa, Hiroki Hoshikawa, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota

Research output: Contribution to journalArticle

Abstract

Synthetic studies of enacyloxins (ENXs), a series of yellow-colored, polyene-polyol antibiotics produced by Frateuria sp. W-315, are described. The C1'-C8' polyene fragments were prepared using successive Wittig reactions. The C9'-C15' and C10'-C15' fragments were constructed from (S)-isopropylideneglyceraldehyde using Yamaguchi's nucleophilic substitution reaction of acetylide to epoxide, and/or Marshall's allenylindium mediated reaction as the key steps.

Original languageEnglish
Pages (from-to)645-648
Number of pages4
JournalNatural product communications
Volume10
Issue number4
Publication statusPublished - 2015

Keywords

  • Antibiotics
  • Elongation factor Tu
  • Enacyloxins
  • Synthetic studies

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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