Synthetic studies of enacyloxins: a series of antibiotics isolated from Frateuria sp. W-315: C1'-C8' and C9'-C15' fragments

Aki Saito, Wataru Igarashi, Hiroyuki Furukawa, Hiroki Hoshikawa, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota

Research output: Contribution to journalArticle

Abstract

Synthetic studies of enacyloxins (ENXs), a series of yellow-colored, polyene-polyol antibiotics produced by Frateuria sp. W-315, are described. The C1'-C8' polyene fragments were prepared using successive Wittig reactions. The C9'-C15' and C10'-C15' fragments were constructed from (S)-isopropylideneglyceraldehyde using Yamaguchi's nucleophilic substitution reaction of acetylide to epoxide, and/or Marshall's allenylindium mediated reaction as the key steps.

Original languageEnglish
Pages (from-to)645-648
Number of pages4
JournalNatural Product Communications
Volume10
Issue number4
Publication statusPublished - Apr 1 2015

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Frateuria
Polyenes
antibiotics
Anti-Bacterial Agents
polyols
Epoxy Compounds
epoxides
polyenes

ASJC Scopus subject areas

  • Medicine(all)

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Synthetic studies of enacyloxins : a series of antibiotics isolated from Frateuria sp. W-315: C1'-C8' and C9'-C15' fragments. / Saito, Aki; Igarashi, Wataru; Furukawa, Hiroyuki; Hoshikawa, Hiroki; Yamada, Teiko; Kuwahara, Shigefumi; Kiyota, Hiromasa.

In: Natural Product Communications, Vol. 10, No. 4, 01.04.2015, p. 645-648.

Research output: Contribution to journalArticle

Saito, A, Igarashi, W, Furukawa, H, Hoshikawa, H, Yamada, T, Kuwahara, S & Kiyota, H 2015, 'Synthetic studies of enacyloxins: a series of antibiotics isolated from Frateuria sp. W-315: C1'-C8' and C9'-C15' fragments', Natural Product Communications, vol. 10, no. 4, pp. 645-648.
Saito A, Igarashi W, Furukawa H, Hoshikawa H, Yamada T, Kuwahara S et al. Synthetic studies of enacyloxins: a series of antibiotics isolated from Frateuria sp. W-315: C1'-C8' and C9'-C15' fragments. Natural Product Communications. 2015 Apr 1;10(4):645-648.
Saito, Aki ; Igarashi, Wataru ; Furukawa, Hiroyuki ; Hoshikawa, Hiroki ; Yamada, Teiko ; Kuwahara, Shigefumi ; Kiyota, Hiromasa. / Synthetic studies of enacyloxins : a series of antibiotics isolated from Frateuria sp. W-315: C1'-C8' and C9'-C15' fragments. In: Natural Product Communications. 2015 ; Vol. 10, No. 4. pp. 645-648.
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