Synthetic cobalt bleomycin models as a photochemical DNA cleaver

Isao Saito, Takashi Morii, Tatsuhiko Obayashi, Takashi Sera, Hiroshi Sugiyama, Teruo Matsuura

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Simplified synthetic models of the bleomycin cobalt complex which contain the AMPHIS {N-[6-(2-aminoethylaminomethyl)pyridin-2-ylcarbonyl]histidine} metal-ion binding ligand and DNA binding component have been prepared; the cobalt complexes cleaved DNA upon photoirradiation.

Original languageEnglish
Pages (from-to)360-362
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number6
DOIs
Publication statusPublished - Jan 1 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Medicine

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