Synthetic cobalt bleomycin models as a photochemical DNA cleaver

Isao Saito, Takashi Morii, Tatsuhiko Obayashi, Takashi Sera, Hiroshi Sugiyama, Teruo Matsuura

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Simplified synthetic models of the bleomycin cobalt complex which contain the AMPHIS {N-[6-(2-aminoethylaminomethyl)pyridin-2-ylcarbonyl]histidine} metal-ion binding ligand and DNA binding component have been prepared; the cobalt complexes cleaved DNA upon photoirradiation.

Original languageEnglish
Pages (from-to)360-362
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number6
DOIs
Publication statusPublished - 1989
Externally publishedYes

Fingerprint

Galium
Cobalt
DNA
Histidine
Metal ions
Metals
Ligands
Ions
cobalt bleomycin

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Synthetic cobalt bleomycin models as a photochemical DNA cleaver. / Saito, Isao; Morii, Takashi; Obayashi, Tatsuhiko; Sera, Takashi; Sugiyama, Hiroshi; Matsuura, Teruo.

In: Journal of the Chemical Society, Chemical Communications, No. 6, 1989, p. 360-362.

Research output: Contribution to journalArticle

Saito, Isao ; Morii, Takashi ; Obayashi, Tatsuhiko ; Sera, Takashi ; Sugiyama, Hiroshi ; Matsuura, Teruo. / Synthetic cobalt bleomycin models as a photochemical DNA cleaver. In: Journal of the Chemical Society, Chemical Communications. 1989 ; No. 6. pp. 360-362.
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