Abstract
The spiroacetal [C(9)-C(20)] fragments of spirofungins A and B, antibiotics isolated from Streptomyces violaceusniger Tü 4113, were prepared from a known bromo alcohol derived from (S)-citronellal, using thermodynamically controlled iodolactonization and spiroacetalization as the key steps.
| Original language | English |
|---|---|
| Pages (from-to) | 337-343 |
| Number of pages | 7 |
| Journal | Heterocyclic Communications |
| Volume | 21 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 1 2015 |
Keywords
- Streptomyces violaceusniger Tü 4113
- acetylide
- antibiotics
- iodolactonization
- selenolactonization
- spiroacetalization
- spirofungins A and B
- synthesis
ASJC Scopus subject areas
- Organic Chemistry
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Cite this
Sakauchi, H., Higashi, E., Shimizu, Y., Kojima, M., Asamitsu, Y., Kuwahara, S., Izumi, M., & Kiyota, H. (2015). Synthesis of the spiroacetal fragments of spirofungins A and B, antibiotics isolated from Streptomyces violaceusniger Tü 4113. Heterocyclic Communications, 21(6), 337-343. https://doi.org/10.1515/hc-2015-0193