Synthesis of the spiroacetal fragments of spirofungins A and B, antibiotics isolated from Streptomyces violaceusniger Tü 4113

Hiroyuki Sakauchi, Emi Higashi, Yuko Shimizu, Mikiko Kojima, Yuko Asamitsu, Shigefumi Kuwahara, Minoru Izumi, Hiromasa Kiyota

Research output: Contribution to journalArticle

Abstract

The spiroacetal [C(9)-C(20)] fragments of spirofungins A and B, antibiotics isolated from Streptomyces violaceusniger Tü 4113, were prepared from a known bromo alcohol derived from (S)-citronellal, using thermodynamically controlled iodolactonization and spiroacetalization as the key steps.

Original languageEnglish
Pages (from-to)337-343
Number of pages7
JournalHeterocyclic Communications
Volume21
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Streptomyces violaceusniger Tü 4113
  • acetylide
  • antibiotics
  • iodolactonization
  • selenolactonization
  • spiroacetalization
  • spirofungins A and B
  • synthesis

ASJC Scopus subject areas

  • Organic Chemistry

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