Synthesis of the ninth component of guinea pig complement (C9) in response to experimentally induced inflammation

M. Takahashi; S. Kawachi Takahashi; K. Yamamoto

doi:10.1159/000231279

Synthesis of the ninth component of guinea pig complement (C9) in response to experimentally induced inflammation

M. Takahashi, S. Kawachi Takahashi, K. Yamamoto

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Effect of turpentine induced inflammation on the serum content of C9 was studied in guinea pigs. A transient increase in the serum content as measured by an immunochemical method of Mancini was observed in all guinea pigs suffering from inflammation. The serum C9 reached a maximum of approximately 200% of the initial serum level at 4 days after the injection of inflammatory agent. From studies involving incorporation of [¹⁴C]leucine into C9, it was shown that the rate of C9 synthesis in guinea pigs with turpentine induced inflammation was increased significantly over that observed in normal guinea pigs.

Original language	English
Pages (from-to)	887-893
Number of pages	7
Journal	International Archives of Allergy and Applied Immunology
Volume	47
Issue number	6
DOIs	https://doi.org/10.1159/000231279
Publication status	Published - 1974
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy

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AB - Effect of turpentine induced inflammation on the serum content of C9 was studied in guinea pigs. A transient increase in the serum content as measured by an immunochemical method of Mancini was observed in all guinea pigs suffering from inflammation. The serum C9 reached a maximum of approximately 200% of the initial serum level at 4 days after the injection of inflammatory agent. From studies involving incorporation of [14C]leucine into C9, it was shown that the rate of C9 synthesis in guinea pigs with turpentine induced inflammation was increased significantly over that observed in normal guinea pigs.

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