Synthesis of the L-acid (C1-C18) fragment of pamamycin-593 and De-N-methylpamamycin-579

Ayako Miura, Shin Ya Takigawa, Yukito Furuya, Yusuke Yokoo, Shigefumi Kuwahara, Hiromasa Kiyota

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The L-acid (C1-C18) fragment of pamamycin-593 and de-N-methylpamamycin-579, strong aerial mycelium-inducers of Streptomyces alboniger, was synthesized using a cis-selective iodoetherification and a nucleophilic addition of a cerium acetylide to an aldehyde as the key steps.

Original languageEnglish
Pages (from-to)4955-4962
Number of pages8
JournalEuropean Journal of Organic Chemistry
Issue number29
DOIs
Publication statusPublished - Oct 1 2008
Externally publishedYes

Keywords

  • Antibiotics
  • Cerium acetylide
  • Iodoetherification
  • Pamamycins
  • Synthesis design

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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