Synthesis of the J ring segment of gambieric acid

Isao Kadota, Hiroyoshi Takamura, Yoshinori Yamamoto

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


The J ring segment 2 of gambieric acid was synthesized stereoselectively by the coupling between the cyclic ether component 3 and the alkenyl iodide 4. The tetrahydropyran 3 was stereoselectively synthesized by the 6-endo-cyclization of a hydroxyepoxide prepared from deoxy-D-ribose. The side chain moiety 4 was prepared by the stereoselective hydrostannation of an internal alkyne.

Original languageEnglish
Pages (from-to)3649-3651
Number of pages3
JournalTetrahedron Letters
Issue number21
Publication statusPublished - May 21 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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