Synthesis of the CD ring system of paclitaxel by atom-transfer radical annulation reaction

Takehiko Yoshimitsu, Hideyuki Nakajima, Hiroto Nagaoka

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Atom-transfer radical annulation of diene derived from D-glucose under Kharasch conditions provided access to the fully functionalized CD ring system of paclitaxel.

Original languageEnglish
Pages (from-to)8587-8590
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number47
DOIs
Publication statusPublished - Nov 18 2002
Externally publishedYes

Fingerprint

Paclitaxel
Glucose
Atoms

Keywords

  • Annulation
  • Radicals and radical reactions
  • Taxoids

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Synthesis of the CD ring system of paclitaxel by atom-transfer radical annulation reaction. / Yoshimitsu, Takehiko; Nakajima, Hideyuki; Nagaoka, Hiroto.

In: Tetrahedron Letters, Vol. 43, No. 47, 18.11.2002, p. 8587-8590.

Research output: Contribution to journalArticle

Yoshimitsu, Takehiko ; Nakajima, Hideyuki ; Nagaoka, Hiroto. / Synthesis of the CD ring system of paclitaxel by atom-transfer radical annulation reaction. In: Tetrahedron Letters. 2002 ; Vol. 43, No. 47. pp. 8587-8590.
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