Synthesis of sominone and its derivatives based on an RCM strategy: Discovery of a novel anti-alzheimer's disease medicine candidate "denosomin"

Yuji Matsuya, Yu Ichiro Yamakawa, Chihiro Tohda, Kiyoshi Teshigawara, Masashi Yamada, Hideo Nemoto

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

(Figure Presrnted) Synthesis of sominone was achieved starting from dehydroepiandrosterone on the basis of an RCM strategy for the construction of a δ-lactone side chain. This synthetic protocol was applied for the synthesis of several analogous derivatives including 1-deoxy-24-norsominone (denosomin), which was revealed to exhibit notable bioactivities for new antidementia chemotherapy, exceeding the original natural compound sominone.

Original languageEnglish
Pages (from-to)3970-3973
Number of pages4
JournalOrganic Letters
Volume11
Issue number17
DOIs
Publication statusPublished - Sep 3 2009
Externally publishedYes

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medicine
Medicine
Alzheimer Disease
Derivatives
Chemotherapy
Dehydroepiandrosterone
Lactones
chemotherapy
synthesis
Bioactivity
Drug Therapy
sominone

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Synthesis of sominone and its derivatives based on an RCM strategy : Discovery of a novel anti-alzheimer's disease medicine candidate "denosomin". / Matsuya, Yuji; Yamakawa, Yu Ichiro; Tohda, Chihiro; Teshigawara, Kiyoshi; Yamada, Masashi; Nemoto, Hideo.

In: Organic Letters, Vol. 11, No. 17, 03.09.2009, p. 3970-3973.

Research output: Contribution to journalArticle

Matsuya, Yuji ; Yamakawa, Yu Ichiro ; Tohda, Chihiro ; Teshigawara, Kiyoshi ; Yamada, Masashi ; Nemoto, Hideo. / Synthesis of sominone and its derivatives based on an RCM strategy : Discovery of a novel anti-alzheimer's disease medicine candidate "denosomin". In: Organic Letters. 2009 ; Vol. 11, No. 17. pp. 3970-3973.
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