Synthesis of sominone and its derivatives based on an RCM strategy: Discovery of a novel anti-alzheimer's disease medicine candidate "denosomin"

Yuji Matsuya, Yu Ichiro Yamakawa, Chihiro Tohda, Kiyoshi Teshigawara, Masashi Yamada, Hideo Nemoto

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

(Figure Presrnted) Synthesis of sominone was achieved starting from dehydroepiandrosterone on the basis of an RCM strategy for the construction of a δ-lactone side chain. This synthetic protocol was applied for the synthesis of several analogous derivatives including 1-deoxy-24-norsominone (denosomin), which was revealed to exhibit notable bioactivities for new antidementia chemotherapy, exceeding the original natural compound sominone.

Original languageEnglish
Pages (from-to)3970-3973
Number of pages4
JournalOrganic Letters
Volume11
Issue number17
DOIs
Publication statusPublished - Sep 3 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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