Synthesis of oxindoles by palladium-catalyzed C-H bond amidation

Tomoya Miura, Yoshiteru Ito, Masahiro Murakami

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Treatment of N-tosylphenylacetamide derivatives with cop-per(II) acetate in the presence of a catalytic amount of palladi-um(II) acetate affords 3,3-disubstituted oxindoles. The reaction proceeds through the intramolecular metallation of an aromatic C-H bond and the following C-N bond formation by reductive elimination.

Original languageEnglish
Pages (from-to)328-329
Number of pages2
JournalChemistry Letters
Volume38
Issue number4
DOIs
Publication statusPublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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