Abstract
Novel water-soluble conjugates of 1,2,4,5-tetraoxane bis(quaternary ammonium salts) were synthesized in a relatively stable crystalline form via four steps starting from methyltrioxorhenium-catalyzed endo-peroxidation of ethyl 4-oxocyclohexanecarboxylate with hydrogen peroxide in hexafluoro-2- propanol. The assay for the in vitro toxicity of water-soluble tetraoxanes 5a-5d to malaria parasites indicate that they were inactive against the Plasmodium falciparum FCR-3 strain.
Original language | English |
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Pages (from-to) | 217-220 |
Number of pages | 4 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 73 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2009 |
Keywords
- Bis(quaternary ammonium salts)
- Malaria
- Reactive oxygen species
- Tetraoxane
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry