Synthesis of novel conjugates of tetraoxane endoperoxide with bis(quaternary ammonium salts)

Naokazu Kumura, Hirotaka Furukawa, Michiyo Kobayashi, Arnold N. Onyango, Minoru Izumi, Shuhei Nakajima, Hye Sook Kim, Yusuke Wataya, Naomichi Baba

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Novel water-soluble conjugates of 1,2,4,5-tetraoxane bis(quaternary ammonium salts) were synthesized in a relatively stable crystalline form via four steps starting from methyltrioxorhenium-catalyzed endo-peroxidation of ethyl 4-oxocyclohexanecarboxylate with hydrogen peroxide in hexafluoro-2- propanol. The assay for the in vitro toxicity of water-soluble tetraoxanes 5a-5d to malaria parasites indicate that they were inactive against the Plasmodium falciparum FCR-3 strain.

Original languageEnglish
Pages (from-to)217-220
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number1
DOIs
Publication statusPublished - Feb 2 2009

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Keywords

  • Bis(quaternary ammonium salts)
  • Malaria
  • Reactive oxygen species
  • Tetraoxane

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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