Synthesis of novel conjugates of tetraoxane endoperoxide with bis(quaternary ammonium salts)

Naokazu Kumura; Hirotaka Furukawa; Michiyo Kobayashi; Arnold N. Onyango; Minoru Izumi; Shuhei Nakajima; Hye Sook Kim; Yusuke Wataya; Naomichi Baba

doi:10.1271/bbb.80571

Synthesis of novel conjugates of tetraoxane endoperoxide with bis(quaternary ammonium salts)

Naokazu Kumura, Hirotaka Furukawa, Michiyo Kobayashi, Arnold N. Onyango, Minoru Izumi, Shuhei Nakajima, Hye Sook Kim, Yusuke Wataya, Naomichi Baba

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Novel water-soluble conjugates of 1,2,4,5-tetraoxane bis(quaternary ammonium salts) were synthesized in a relatively stable crystalline form via four steps starting from methyltrioxorhenium-catalyzed endo-peroxidation of ethyl 4-oxocyclohexanecarboxylate with hydrogen peroxide in hexafluoro-2- propanol. The assay for the in vitro toxicity of water-soluble tetraoxanes 5a-5d to malaria parasites indicate that they were inactive against the Plasmodium falciparum FCR-3 strain.

Original language	English
Pages (from-to)	217-220
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	73
Issue number	1
DOIs	https://doi.org/10.1271/bbb.80571
Publication status	Published - Feb 2 2009

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Keywords

Bis(quaternary ammonium salts)
Malaria
Reactive oxygen species
Tetraoxane

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

Cite this

Kumura, N., Furukawa, H., Kobayashi, M., Onyango, A. N., Izumi, M., Nakajima, S., Kim, H. S., Wataya, Y., & Baba, N. (2009). Synthesis of novel conjugates of tetraoxane endoperoxide with bis(quaternary ammonium salts). Bioscience, Biotechnology and Biochemistry, 73(1), 217-220. https://doi.org/10.1271/bbb.80571

Synthesis of novel conjugates of tetraoxane endoperoxide with bis(quaternary ammonium salts). / Kumura, Naokazu; Furukawa, Hirotaka; Kobayashi, Michiyo; Onyango, Arnold N.; Izumi, Minoru; Nakajima, Shuhei; Kim, Hye Sook; Wataya, Yusuke; Baba, Naomichi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 73, No. 1, 02.02.2009, p. 217-220.

Research output: Contribution to journal › Article

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10.1271/bbb.80571