Synthesis of nitric oxide from the two equivalent guanidino nitrogens of L-arginine by Lactobacillus fermentum

Hidetoshi Morita, Hiroshi Yoshikawa, Ryoichi Sakata, Yukiharu Nagata, Hidehiko Tanaka

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Ten strains of Lactobacillus fermentum that differed in origin converted metmyoglobin to nitrosylmyoglobin [a pentacoordinate nitric oxide (NO) complex of Fe(II) myoglobin] in MRS broth at pH 4.3. Of the 10 strains, L. fermentum IFO 3956 possessed the strongest capacity to convert metmyoglobin to nitrosylmyoglobin. This strain synthesizes NO enzymatically from the two equivalent guanidino nitrogens of L-arginine. To our knowledge, this demonstrates for the first time the production of NO synthesized from the guanidino nitrogens of L-arginine by lactic acid bacteria. IFO 3956 may possess a bacterial NO synthase.

Original languageEnglish
Pages (from-to)7812-7815
Number of pages4
JournalJournal of Bacteriology
Volume179
Issue number24
Publication statusPublished - Dec 1997
Externally publishedYes

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Lactobacillus fermentum
Metmyoglobin
Arginine
Nitric Oxide
Nitrogen
Myoglobin
Nitric Oxide Synthase
Lactic Acid
Bacteria
myoglobin nitroxide

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

Cite this

Synthesis of nitric oxide from the two equivalent guanidino nitrogens of L-arginine by Lactobacillus fermentum. / Morita, Hidetoshi; Yoshikawa, Hiroshi; Sakata, Ryoichi; Nagata, Yukiharu; Tanaka, Hidehiko.

In: Journal of Bacteriology, Vol. 179, No. 24, 12.1997, p. 7812-7815.

Research output: Contribution to journalArticle

Morita, Hidetoshi ; Yoshikawa, Hiroshi ; Sakata, Ryoichi ; Nagata, Yukiharu ; Tanaka, Hidehiko. / Synthesis of nitric oxide from the two equivalent guanidino nitrogens of L-arginine by Lactobacillus fermentum. In: Journal of Bacteriology. 1997 ; Vol. 179, No. 24. pp. 7812-7815.
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