Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization

Haruki Mizoguchi, Ryo Watanabe, Shintaro Minami, Hideaki Oikawa, Hiroki Oguri

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Copper-catalyzed 6-endo cyclization of N-propargylic β-enaminocarbonyls was developed for the synthesis of oxidation-labile 1,6-dihydropyridines. This synthetic method allows flexible and regio-defined assembly of various substituents at the N1, C2, C3, C4, and C6 positions of 1,6-dihydropyridines under mild conditions.

Original languageEnglish
Pages (from-to)5955-5963
Number of pages9
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number21
DOIs
Publication statusPublished - Jun 7 2015
Externally publishedYes

Fingerprint

Dihydropyridines
Cyclization
assembly
copper
oxidation
synthesis
Copper
Oxidation
endo-alpha-sialidase

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization. / Mizoguchi, Haruki; Watanabe, Ryo; Minami, Shintaro; Oikawa, Hideaki; Oguri, Hiroki.

In: Organic and Biomolecular Chemistry, Vol. 13, No. 21, 07.06.2015, p. 5955-5963.

Research output: Contribution to journalArticle

Mizoguchi, Haruki ; Watanabe, Ryo ; Minami, Shintaro ; Oikawa, Hideaki ; Oguri, Hiroki. / Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization. In: Organic and Biomolecular Chemistry. 2015 ; Vol. 13, No. 21. pp. 5955-5963.
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