Abstract
Macrotetrolide α, a designed analog of polynactin composed of (+)- and (-)-bishomononactic acids, was synthesized. These monomers were prepared via optical resolution of the corresponding (S)-O-acetylmandelates. Assembly of the monomers to macrotetrolide a look seven steps without any loss of the intermediates.
Original language | English |
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Pages (from-to) | 2118-2120 |
Number of pages | 3 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 65 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sep 1 2001 |
Externally published | Yes |
Keywords
- Bishomononactate
- Macrotetrolide
- Optical resolution
- Polynactin
- Total synthesis
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry