Synthesis of Macrotetrolide α, a Designed Polynactin Analog Composed of (+)- and (-)-Bishomononactic Acids

Tadaatsu Hanadate; Hiromasa Kiyota; Takayuki Oritani

doi:10.1271/bbb.65.2118

Synthesis of Macrotetrolide α, a Designed Polynactin Analog Composed of (+)- and (-)-Bishomononactic Acids

Tadaatsu Hanadate, Hiromasa Kiyota, Takayuki Oritani

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Macrotetrolide α, a designed analog of polynactin composed of (+)- and (-)-bishomononactic acids, was synthesized. These monomers were prepared via optical resolution of the corresponding (S)-O-acetylmandelates. Assembly of the monomers to macrotetrolide a look seven steps without any loss of the intermediates.

Original language	English
Pages (from-to)	2118-2120
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	65
Issue number	9
DOIs	https://doi.org/10.1271/bbb.65.2118
Publication status	Published - Sep 1 2001
Externally published	Yes

Keywords

Bishomononactate
Macrotetrolide
Optical resolution
Polynactin
Total synthesis

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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abstract = "Macrotetrolide α, a designed analog of polynactin composed of (+)- and (-)-bishomononactic acids, was synthesized. These monomers were prepared via optical resolution of the corresponding (S)-O-acetylmandelates. Assembly of the monomers to macrotetrolide a look seven steps without any loss of the intermediates.",

keywords = "Bishomononactate, Macrotetrolide, Optical resolution, Polynactin, Total synthesis",

author = "Tadaatsu Hanadate and Hiromasa Kiyota and Takayuki Oritani",

year = "2001",

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T1 - Synthesis of Macrotetrolide α, a Designed Polynactin Analog Composed of (+)- and (-)-Bishomononactic Acids

AU - Hanadate, Tadaatsu

AU - Kiyota, Hiromasa

AU - Oritani, Takayuki

PY - 2001/9/1

Y1 - 2001/9/1

N2 - Macrotetrolide α, a designed analog of polynactin composed of (+)- and (-)-bishomononactic acids, was synthesized. These monomers were prepared via optical resolution of the corresponding (S)-O-acetylmandelates. Assembly of the monomers to macrotetrolide a look seven steps without any loss of the intermediates.

AB - Macrotetrolide α, a designed analog of polynactin composed of (+)- and (-)-bishomononactic acids, was synthesized. These monomers were prepared via optical resolution of the corresponding (S)-O-acetylmandelates. Assembly of the monomers to macrotetrolide a look seven steps without any loss of the intermediates.

KW - Bishomononactate

KW - Macrotetrolide

KW - Optical resolution

KW - Polynactin

KW - Total synthesis

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