Synthesis of lipid derivatives of pyrrole polyamide and their biological activity

Masahiko Yamamoto, Changjin Zhu, Lui Yi, Zheng Rong, Yoshie Miura, Minoru Izumi, Shuhei Nakajima, Ken Ichi Tanamoto, Sakayu Shimizu, Naomichi Baba

Research output: Contribution to journalArticle

Abstract

Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.

Original languageEnglish
Pages (from-to)1078-1082
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume71
Issue number4
DOIs
Publication statusPublished - May 1 2007

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Keywords

  • Cancer cell
  • Human immunodeficiency virus (HIV)-II
  • Lipid
  • Phospholipid
  • Pyrrole polyamide

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Yamamoto, M., Zhu, C., Yi, L., Rong, Z., Miura, Y., Izumi, M., Nakajima, S., Tanamoto, K. I., Shimizu, S., & Baba, N. (2007). Synthesis of lipid derivatives of pyrrole polyamide and their biological activity. Bioscience, Biotechnology and Biochemistry, 71(4), 1078-1082. https://doi.org/10.1271/bbb.60650