Synthesis of lipid derivatives of pyrrole polyamide and their biological activity

Masahiko Yamamoto, Changjin Zhu, Lui Yi, Zheng Rong, Yoshie Miura, Minoru Izumi, Shuhei Nakajima, Ken Ichi Tanamoto, Sakayu Shimizu, Naomichi Baba

Research output: Contribution to journalArticle

Abstract

Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.

Original languageEnglish
Pages (from-to)1078-1082
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume71
Issue number4
DOIs
Publication statusPublished - 2007

Fingerprint

pyrroles
Pyrroles
Nylons
Human immunodeficiency virus
Bioactivity
Viruses
Polyamides
Lipids
bioactive properties
chemical derivatives
Cells
HIV
Derivatives
synthesis
Phospholipids
Cytotoxicity
lipids
cytotoxicity
Neoplasms
phospholipids

Keywords

  • Cancer cell
  • Human immunodeficiency virus (HIV)-II
  • Lipid
  • Phospholipid
  • Pyrrole polyamide

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Food Science

Cite this

Synthesis of lipid derivatives of pyrrole polyamide and their biological activity. / Yamamoto, Masahiko; Zhu, Changjin; Yi, Lui; Rong, Zheng; Miura, Yoshie; Izumi, Minoru; Nakajima, Shuhei; Tanamoto, Ken Ichi; Shimizu, Sakayu; Baba, Naomichi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 71, No. 4, 2007, p. 1078-1082.

Research output: Contribution to journalArticle

Yamamoto, M, Zhu, C, Yi, L, Rong, Z, Miura, Y, Izumi, M, Nakajima, S, Tanamoto, KI, Shimizu, S & Baba, N 2007, 'Synthesis of lipid derivatives of pyrrole polyamide and their biological activity', Bioscience, Biotechnology and Biochemistry, vol. 71, no. 4, pp. 1078-1082. https://doi.org/10.1271/bbb.60650
Yamamoto, Masahiko ; Zhu, Changjin ; Yi, Lui ; Rong, Zheng ; Miura, Yoshie ; Izumi, Minoru ; Nakajima, Shuhei ; Tanamoto, Ken Ichi ; Shimizu, Sakayu ; Baba, Naomichi. / Synthesis of lipid derivatives of pyrrole polyamide and their biological activity. In: Bioscience, Biotechnology and Biochemistry. 2007 ; Vol. 71, No. 4. pp. 1078-1082.
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AU - Nakajima, Shuhei

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