Synthesis of gem-difluoroalkenes via β-fluoride elimination of organorhodium(I)

Tomoya Miura; Yoshiteru Ito; Masahiro Murakami

doi:10.1246/cl.2008.1006

Synthesis of gem-difluoroalkenes via β-fluoride elimination of organorhodium(I)

Tomoya Miura, Yoshiteru Ito, Masahiro Murakami

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93 Citations (Scopus)

Abstract

Treatment of α-(trifluoromethyl)styrenes with arylboronic esters and MeMgCl in the presence of a rhodium(I) catalyst affords gem-difluoroalkenes. The reaction proceeds through the addition of arylrhodium(I) species across the electron-deficient carbon-carbon double bond and the subsequent β-fluoride elimination.

Original language	English
Pages (from-to)	1006-1007
Number of pages	2
Journal	Chemistry Letters
Volume	37
Issue number	9
DOIs	https://doi.org/10.1246/cl.2008.1006
Publication status	Published - Sept 5 2008
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.2008.1006

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title = "Synthesis of gem-difluoroalkenes via β-fluoride elimination of organorhodium(I)",

abstract = "Treatment of α-(trifluoromethyl)styrenes with arylboronic esters and MeMgCl in the presence of a rhodium(I) catalyst affords gem-difluoroalkenes. The reaction proceeds through the addition of arylrhodium(I) species across the electron-deficient carbon-carbon double bond and the subsequent β-fluoride elimination.",

author = "Tomoya Miura and Yoshiteru Ito and Masahiro Murakami",

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AU - Miura, Tomoya

AU - Ito, Yoshiteru

AU - Murakami, Masahiro

PY - 2008/9/5

Y1 - 2008/9/5

N2 - Treatment of α-(trifluoromethyl)styrenes with arylboronic esters and MeMgCl in the presence of a rhodium(I) catalyst affords gem-difluoroalkenes. The reaction proceeds through the addition of arylrhodium(I) species across the electron-deficient carbon-carbon double bond and the subsequent β-fluoride elimination.

AB - Treatment of α-(trifluoromethyl)styrenes with arylboronic esters and MeMgCl in the presence of a rhodium(I) catalyst affords gem-difluoroalkenes. The reaction proceeds through the addition of arylrhodium(I) species across the electron-deficient carbon-carbon double bond and the subsequent β-fluoride elimination.

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JO - Chemistry Letters

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Synthesis of gem-difluoroalkenes via β-fluoride elimination of organorhodium(I)

Abstract

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