Synthesis of gem-difluoroalkenes via β-fluoride elimination of organorhodium(I)

Tomoya Miura, Yoshiteru Ito, Masahiro Murakami

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)


Treatment of α-(trifluoromethyl)styrenes with arylboronic esters and MeMgCl in the presence of a rhodium(I) catalyst affords gem-difluoroalkenes. The reaction proceeds through the addition of arylrhodium(I) species across the electron-deficient carbon-carbon double bond and the subsequent β-fluoride elimination.

Original languageEnglish
Pages (from-to)1006-1007
Number of pages2
JournalChemistry Letters
Issue number9
Publication statusPublished - Sept 5 2008
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)


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