Synthesis of Enantiopure C3-Symmetric Triangular Molecules

Tomoya Miura, Takayuki Nakamuro, Scott G. Stewart, Yuuya Nagata, Masahiro Murakami

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


An asymmetric synthesis of C3-symmetric triangular macrocycles is reported. 1-Methylsulfonyl-4-(4-vinylphenyl)-1,2,3-triazole undergoes a rhodium(II)-catalyzed cyclotrimerization to establish an enantiopure C3-symmetric triangular macrocycle motif. This method can be applied to the synthesis of an enantiopure hydrocarbon, which owes its chirality to asymmetric distribution of H/D atoms on the benzene rings.

Original languageEnglish
Pages (from-to)3334-3338
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number12
Publication statusPublished - Mar 13 2017
Externally publishedYes


  • asymmetric synthesis
  • C-symmetry
  • cyclotrimerization
  • macrocycles
  • rhodium

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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