Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene

Takuya Kumamoto, Naho Aoyama, Satoko Nakano, Tsutomu Ishikawa, Shizuo Narimatsu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Both (R)- and (S)-enantiomers of 4-hydroxypropranolol were effectively prepared from 1,4-dihydroxynaphthalene in eight steps. The overall yields were around 30%.

Original languageEnglish
Pages (from-to)791-795
Number of pages5
JournalTetrahedron Asymmetry
Volume12
Issue number5
DOIs
Publication statusPublished - Apr 2 2001

Fingerprint

Enantiomers
enantiomers
synthesis
1,4-naphthohydroquinone
4-hydroxypropranolol

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Kumamoto, T., Aoyama, N., Nakano, S., Ishikawa, T., & Narimatsu, S. (2001). Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene. Tetrahedron Asymmetry, 12(5), 791-795. https://doi.org/10.1016/S0957-4166(01)00122-7

Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene. / Kumamoto, Takuya; Aoyama, Naho; Nakano, Satoko; Ishikawa, Tsutomu; Narimatsu, Shizuo.

In: Tetrahedron Asymmetry, Vol. 12, No. 5, 02.04.2001, p. 791-795.

Research output: Contribution to journalArticle

Kumamoto, T, Aoyama, N, Nakano, S, Ishikawa, T & Narimatsu, S 2001, 'Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene', Tetrahedron Asymmetry, vol. 12, no. 5, pp. 791-795. https://doi.org/10.1016/S0957-4166(01)00122-7
Kumamoto, Takuya ; Aoyama, Naho ; Nakano, Satoko ; Ishikawa, Tsutomu ; Narimatsu, Shizuo. / Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene. In: Tetrahedron Asymmetry. 2001 ; Vol. 12, No. 5. pp. 791-795.
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