Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene

Takuya Kumamoto, Naho Aoyama, Satoko Nakano, Tsutomu Ishikawa, Shizuo Narimatsu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Both (R)- and (S)-enantiomers of 4-hydroxypropranolol were effectively prepared from 1,4-dihydroxynaphthalene in eight steps. The overall yields were around 30%.

Original languageEnglish
Pages (from-to)791-795
Number of pages5
JournalTetrahedron Asymmetry
Volume12
Issue number5
DOIs
Publication statusPublished - Apr 2 2001

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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    Kumamoto, T., Aoyama, N., Nakano, S., Ishikawa, T., & Narimatsu, S. (2001). Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene. Tetrahedron Asymmetry, 12(5), 791-795. https://doi.org/10.1016/S0957-4166(01)00122-7