Synthesis of Enamines, Aldehydes, and Nitriles from CO2: Scope of the One-Pot Strategy via Formamides

Koichi Nakaoka, Chao Guo, Yuta Saiki, Shin Furukawa, Tadashi Ema

Research output: Contribution to journalArticlepeer-review

Abstract

Tetrabutylammonium acetate (TBAA) and Cu(OAc)2 worked as a binary catalytic system for the solvent-free N-formylation of amines with CO2 and PhSiH3. This catalysis making C-H and C-N bonds with CO2 was coupled with the C-C bond-forming reactions to achieve the one-pot synthesis of enamines, aldehydes, and nitriles. The X-ray crystal structure of a Cu(OAc)2-TBAA complex was also revealed.

Original languageEnglish
JournalJournal of Organic Chemistry
DOIs
Publication statusAccepted/In press - 2022

ASJC Scopus subject areas

  • Organic Chemistry

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