Abstract
Racemic compounds (1 and 2) of the antimalarial agents febrifugine (D-1) and isofebrifugine (D-2) were synthesized using an unusual Claisen rearrangement of allyl enol ether 6 and the stereoselective reduction of 2- allylpiperid-3-one 8. This method is widely applicable to the synthesis of febirifugine derivatives.
| Original language | English |
|---|---|
| Pages (from-to) | 1814-1818 |
| Number of pages | 5 |
| Journal | Synthesis |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Jan 1 1999 |
Keywords
- Antimalarial agent
- Claisen rearrangement
- Febrifugine
- Isofebrifugine
- Stereoselective reduction
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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Cite this
Takeuchi, Y., Hattori, M., Abe, H., & Harayama, T. (1999). Synthesis of D/L-febrifugine and D/L-isofebrifugine. Synthesis, (10), 1814-1818. https://doi.org/10.1055/s-1999-3583