Abstract
Racemic compounds (1 and 2) of the antimalarial agents febrifugine (D-1) and isofebrifugine (D-2) were synthesized using an unusual Claisen rearrangement of allyl enol ether 6 and the stereoselective reduction of 2- allylpiperid-3-one 8. This method is widely applicable to the synthesis of febirifugine derivatives.
Original language | English |
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Pages (from-to) | 1814-1818 |
Number of pages | 5 |
Journal | Synthesis |
Issue number | 10 |
DOIs | |
Publication status | Published - Jan 1 1999 |
Keywords
- Antimalarial agent
- Claisen rearrangement
- Febrifugine
- Isofebrifugine
- Stereoselective reduction
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry