Synthesis of carbonate-hydroxy apatite and selective adsorption activity against specific pathogenic substances

Seisuke Takashima, Y. Kusudo, S. Takemoto, K. Tsuru, Satoshi Hayakawa, A. Osaka

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5 Citations (Scopus)


Hydroxyapatite (HAP) and carbonate-hydroxy apatite (CAP5 and CAP15) were synthesized under the flow of N2 containing 0%, 5%, or 15% CO2 by wet chemical method, and subsequently calcined at 105-700°C. Infrared analysis showed that carbonate ions substituted PO43- and OH- sites. The clotting characteristics for the fresh mixed plasma contacted with the samples indicated that CAP had better blood compatibility than HAP. The protein adsorption activity was evaluated by contacting with the model saline containing bovine serum albumin (BSA) and β2-microgloburin (β2-MG). CAP15 calcined below 600°C adsorbed the lowest fraction of BSA (9%) whereas it adsorbed the highest fraction of β2-MG (47%). It was concluded that the selective adsorption activity against β2-MG was related to the carbonate ions incorporated in hydroxyapatite.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2002



  • β-Microgloburin
  • Blood Compatibility
  • Bovine Serum Albumin
  • Carbonate-Hydroxy Apatite
  • Hydroxyapatite

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

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