Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.

Yukio Kitade; Hiroharu Kojima; Fazila Zulfiqur; Saori Yabe; Daisuke Yamagiwa; Yasutomo Ito; Masayuki Nakanishi; Yoshihito Ueno; Hye Sook Kim; Yusuke Wataya

doi:10.1093/nass/3.1.5

Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.

Yukio Kitade, Hiroharu Kojima, Fazila Zulfiqur, Saori Yabe, Daisuke Yamagiwa, Yasutomo Ito, Masayuki Nakanishi, Yoshihito Ueno, Hye Sook Kim, Yusuke Wataya

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.

Original language	English
Pages (from-to)	5-6
Number of pages	2
Journal	Nucleic acids research. Supplement (2001)
Issue number	3
DOIs	https://doi.org/10.1093/nass/3.1.5
Publication status	Published - 2003
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Kitade, Y., Kojima, H., Zulfiqur, F., Yabe, S., Yamagiwa, D., Ito, Y., Nakanishi, M., Ueno, Y., Kim, H. S., & Wataya, Y. (2003). Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase. Nucleic acids research. Supplement (2001), (3), 5-6. https://doi.org/10.1093/nass/3.1.5

Kitade, Y, Kojima, H, Zulfiqur, F, Yabe, S, Yamagiwa, D, Ito, Y, Nakanishi, M, Ueno, Y, Kim, HS & Wataya, Y 2003, 'Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.', Nucleic acids research. Supplement (2001), no. 3, pp. 5-6. https://doi.org/10.1093/nass/3.1.5

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abstract = "Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.",

author = "Yukio Kitade and Hiroharu Kojima and Fazila Zulfiqur and Saori Yabe and Daisuke Yamagiwa and Yasutomo Ito and Masayuki Nakanishi and Yoshihito Ueno and Kim, {Hye Sook} and Yusuke Wataya",

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doi = "10.1093/nass/3.1.5",

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AU - Kitade, Yukio

AU - Kojima, Hiroharu

AU - Zulfiqur, Fazila

AU - Yabe, Saori

AU - Yamagiwa, Daisuke

AU - Ito, Yasutomo

AU - Nakanishi, Masayuki

AU - Ueno, Yoshihito

AU - Kim, Hye Sook

AU - Wataya, Yusuke

PY - 2003

Y1 - 2003

N2 - Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.

AB - Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.

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JO - Nucleic acids research. Supplement (2001)

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IS - 3

ER -

Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.

Abstract

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