Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.

Yukio Kitade; Hiroharu Kojima; Fazila Zulfiqur; Saori Yabe; Daisuke Yamagiwa; Yasutomo Ito; Masayuki Nakanishi; Yoshihito Ueno; Hye Sook Kim; Yusuke Wataya

doi:10.1093/nass/3.1.5

Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.

Yukio Kitade, Hiroharu Kojima, Fazila Zulfiqur, Saori Yabe, Daisuke Yamagiwa, Yasutomo Ito, Masayuki Nakanishi, Yoshihito Ueno, Hye Sook Kim, Yusuke Wataya

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.

Original language	English
Pages (from-to)	5-6
Number of pages	2
Journal	Nucleic acids research. Supplement (2001)
Issue number	3
DOIs	https://doi.org/10.1093/nass/3.1.5
Publication status	Published - 2003
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Kitade, Y., Kojima, H., Zulfiqur, F., Yabe, S., Yamagiwa, D., Ito, Y., Nakanishi, M., Ueno, Y., Kim, H. S., & Wataya, Y. (2003). Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase. Nucleic acids research. Supplement (2001), (3), 5-6. https://doi.org/10.1093/nass/3.1.5

Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase. / Kitade, Yukio; Kojima, Hiroharu; Zulfiqur, Fazila; Yabe, Saori; Yamagiwa, Daisuke; Ito, Yasutomo; Nakanishi, Masayuki; Ueno, Yoshihito; Kim, Hye Sook; Wataya, Yusuke.

In: Nucleic acids research. Supplement (2001), No. 3, 2003, p. 5-6.

Research output: Contribution to journal › Article › peer-review

Kitade, Y, Kojima, H, Zulfiqur, F, Yabe, S, Yamagiwa, D, Ito, Y, Nakanishi, M, Ueno, Y, Kim, HS & Wataya, Y 2003, 'Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.', Nucleic acids research. Supplement (2001), no. 3, pp. 5-6. https://doi.org/10.1093/nass/3.1.5

Kitade, Yukio ; Kojima, Hiroharu ; Zulfiqur, Fazila ; Yabe, Saori ; Yamagiwa, Daisuke ; Ito, Yasutomo ; Nakanishi, Masayuki ; Ueno, Yoshihito ; Kim, Hye Sook ; Wataya, Yusuke. / Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase. In: Nucleic acids research. Supplement (2001). 2003 ; No. 3. pp. 5-6.

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abstract = "Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.",

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AU - Kitade, Yukio

AU - Kojima, Hiroharu

AU - Zulfiqur, Fazila

AU - Yabe, Saori

AU - Yamagiwa, Daisuke

AU - Ito, Yasutomo

AU - Nakanishi, Masayuki

AU - Ueno, Yoshihito

AU - Kim, Hye Sook

AU - Wataya, Yusuke

PY - 2003

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Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.

Abstract

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