Synthesis of both enantiomers of ω-trifluorononactic acid, a new analogue of nonactin monomers

Kentaro Takai, Tadaatsu Hanadate, Shuichi Oi, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Both (+)- and (-)-ω-trifluorononactic acid, a designed analogue of nonactic acid, were synthesized. The racemic acid, prepared by using cis-selective iodoetherification, was resolved as the corresponding (S)-O-acetylmandelates. The structure was determined by X-ray crystallographic analysis.

Original languageEnglish
Article numberF69411SS
Pages (from-to)3741-3748
Number of pages8
JournalSynthesis
Issue number22
DOIs
Publication statusPublished - Sep 21 2011
Externally publishedYes

Keywords

  • antibiotics
  • chiral resolution
  • polynactins
  • total synthesis
  • ω-trifluorononactic acid

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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