Synthesis of biopterin and related pterin glycosides

Tadashi Hanaya, Hiroshi Yamamoto

    Research output: Contribution to journalReview articlepeer-review

    4 Citations (Scopus)

    Abstract

    Certain pterins having a hydroxyalkyl side chain at C-6 have been found as glycosidic forms in certain prokaryotes, such as 2'-O-(α-D-glucopyranosyl) biopterin from various kinds of cyanobacteria, and limipterin from a green sulfur photosynthetic bacterium. Synthetic studies on glycosides of biopterin and related pterins have been made in view of the structural proof as well as for closer examination of their biological activities and functions. The syntheses of these natural pterin glycosides have effectively been achieved, mostly through appropriately protected N2-(N,N- dimethylaminomethylene)-3-[2-(4-nitrophenyl)ethyl]pterin derivatives as glycosyl acceptors, and are reviewed here.

    Original languageEnglish
    Pages (from-to)300-309
    Number of pages10
    JournalIUBMB Life
    Volume65
    Issue number4
    DOIs
    Publication statusPublished - Apr 2013

    Keywords

    • asperopterin-A
    • biopterin
    • ciliapterin
    • glycosylation
    • limipterin
    • neopterin
    • protecting group
    • pteridine
    • pterin glycoside
    • tepidopterin

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Genetics
    • Clinical Biochemistry
    • Cell Biology

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