Synthesis of bioactive HEMA-MPS-CaCl2 hybrid gels: Effects of catalysts in the sol-gel processing on mechanical properties and in vitro hydroxyapatite formation in a simulated body fluid

Tomohiro Uchino, Chikara Ohtsuki, Masanobu Kamitakahara, Toshiki Miyazaki, Satoshi Hayakawa, Akiyoshi Osaka

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We investigated synthetic conditions for the fabrication of bioactive hybrid gels from monomers of 2-hydroxyethylmethacrylate (HEMA) and 3-methacryloxypropyltrimethoxysilane (MPS) in combination with CaCl2, at a starting molar ratio of HEMA: MPS : CaCl2 of 9 : 1 : 1. Hydroxyapatite formation, essential to show bone bonding, was observed on the HEMA- MPS-CaCl2 hybrid gels with the added catalysts NH2 or HCl with a molar ratio to MPS of 0.1, but not on the hybrid gel with HCl at a molar ratio to MPS of 1. The mechanical properties of the gels were dependent on the catalysts, which may affect the microstructures that develop during sol-gel processing.

Original languageEnglish
Pages (from-to)519-532
Number of pages14
JournalJournal of Biomaterials Applications
Issue number6
Publication statusPublished - 2009



  • Bone bonding
  • Hydroxyapatite
  • Mechanical property
  • Simulated body fluid
  • Sol-gel processing

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

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