Synthesis of bioactive and porous organic-inorganic hybrids for biomedical applications

Kanji Tsuru; Satoshi Hayakawa; Akiyoshi Osaka

doi:10.1007/s10971-004-5789-1

Synthesis of bioactive and porous organic-inorganic hybrids for biomedical applications

Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Bioactivity has been exhibited by a limited range of ceramics since the invention of Bioglass®. Recently, some bioactive polymeric organic-inorganic hybrids were introduced, including not only organically modified silicates (Ormosils) synthesized from polydimethylsiloxane (PDMS) and tetraethoxysilane but also those with gelatin and 3-glycidoxypropyl-tremethoxysilane. Preparation of the bulk and porous hybrids and their polymeric structures analyzed by Si NMR spectroscopy were presented. In vitro bioactivity or apatite deposition in a simulated body fluid of the Kokubo recipe were also described for those hybrids. Freeze-drying techniques introduced porosity (up to 90%) and pores extending in a preferred direction.

Original language	English
Pages (from-to)	201-205
Number of pages	5
Journal	Journal of Sol-Gel Science and Technology
Volume	32
Issue number	1-3
DOIs	https://doi.org/10.1007/s10971-004-5789-1
Publication status	Published - Dec 2004

Keywords

Biomedical applications
Hybrids
Porosity
Sol-gel process

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Biomaterials
Condensed Matter Physics
Materials Chemistry

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10.1007/s10971-004-5789-1

Cite this

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AU - Tsuru, Kanji

AU - Hayakawa, Satoshi

AU - Osaka, Akiyoshi

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AB - Bioactivity has been exhibited by a limited range of ceramics since the invention of Bioglass®. Recently, some bioactive polymeric organic-inorganic hybrids were introduced, including not only organically modified silicates (Ormosils) synthesized from polydimethylsiloxane (PDMS) and tetraethoxysilane but also those with gelatin and 3-glycidoxypropyl-tremethoxysilane. Preparation of the bulk and porous hybrids and their polymeric structures analyzed by Si NMR spectroscopy were presented. In vitro bioactivity or apatite deposition in a simulated body fluid of the Kokubo recipe were also described for those hybrids. Freeze-drying techniques introduced porosity (up to 90%) and pores extending in a preferred direction.

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KW - Porosity

KW - Sol-gel process

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Synthesis of bioactive and porous organic-inorganic hybrids for biomedical applications

Abstract

Keywords

ASJC Scopus subject areas

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