Synthesis of benzo[c]phenanthridine alkaloids, using a novel palladium-phosphine combination system - Pd(OAc)2, DPPP, and Bu3P

Takashi Harayama, Toshihiko Akiyama, Yuichiro Nakano, Kentaro Shibaike, Hisashi Akamatsu, Akihiro Hori, Hitoshi Abe, Yasuo Takeuchi

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48 Citations (Scopus)

Abstract

Total synthesis of several benzo[c]phenanthridine alkaloids was accomplished via an aryl-aryl coupling reaction using a novel Pd reagent prepared from Pd(OAc)2 DPPP, and Bu3P. This is a versatile method for the coupling reactions of not only aryl triflates and arenes but also aryl halides and arenes.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalSynthesis
Issue number2
Publication statusPublished - 2002

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Keywords

  • Halo-amide
  • Intramolecular aryl-aryl coupling
  • Palladium reagent
  • Ring closure
  • Triflate-amide

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Harayama, T., Akiyama, T., Nakano, Y., Shibaike, K., Akamatsu, H., Hori, A., Abe, H., & Takeuchi, Y. (2002). Synthesis of benzo[c]phenanthridine alkaloids, using a novel palladium-phosphine combination system - Pd(OAc)2, DPPP, and Bu3P. Synthesis, (2), 237-241.