Synthesis of benzo[c]phenanthridine alkaloids, using a novel palladium-phosphine combination system - Pd(OAc)2, DPPP, and Bu3P

Takashi Harayama, Toshihiko Akiyama, Yuichiro Nakano, Kentaro Shibaike, Hisashi Akamatsu, Akihiro Hori, Hitoshi Abe, Yasuo Takeuchi

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Total synthesis of several benzo[c]phenanthridine alkaloids was accomplished via an aryl-aryl coupling reaction using a novel Pd reagent prepared from Pd(OAc)2 DPPP, and Bu3P. This is a versatile method for the coupling reactions of not only aryl triflates and arenes but also aryl halides and arenes.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalSynthesis
Issue number2
Publication statusPublished - 2002

Fingerprint

phosphine
Phenanthridines
Alkaloids
Palladium
palladium(II) acetate

Keywords

  • Halo-amide
  • Intramolecular aryl-aryl coupling
  • Palladium reagent
  • Ring closure
  • Triflate-amide

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Harayama, T., Akiyama, T., Nakano, Y., Shibaike, K., Akamatsu, H., Hori, A., ... Takeuchi, Y. (2002). Synthesis of benzo[c]phenanthridine alkaloids, using a novel palladium-phosphine combination system - Pd(OAc)2, DPPP, and Bu3P. Synthesis, (2), 237-241.

Synthesis of benzo[c]phenanthridine alkaloids, using a novel palladium-phosphine combination system - Pd(OAc)2, DPPP, and Bu3P. / Harayama, Takashi; Akiyama, Toshihiko; Nakano, Yuichiro; Shibaike, Kentaro; Akamatsu, Hisashi; Hori, Akihiro; Abe, Hitoshi; Takeuchi, Yasuo.

In: Synthesis, No. 2, 2002, p. 237-241.

Research output: Contribution to journalArticle

Harayama, T, Akiyama, T, Nakano, Y, Shibaike, K, Akamatsu, H, Hori, A, Abe, H & Takeuchi, Y 2002, 'Synthesis of benzo[c]phenanthridine alkaloids, using a novel palladium-phosphine combination system - Pd(OAc)2, DPPP, and Bu3P', Synthesis, no. 2, pp. 237-241.
Harayama T, Akiyama T, Nakano Y, Shibaike K, Akamatsu H, Hori A et al. Synthesis of benzo[c]phenanthridine alkaloids, using a novel palladium-phosphine combination system - Pd(OAc)2, DPPP, and Bu3P. Synthesis. 2002;(2):237-241.
Harayama, Takashi ; Akiyama, Toshihiko ; Nakano, Yuichiro ; Shibaike, Kentaro ; Akamatsu, Hisashi ; Hori, Akihiro ; Abe, Hitoshi ; Takeuchi, Yasuo. / Synthesis of benzo[c]phenanthridine alkaloids, using a novel palladium-phosphine combination system - Pd(OAc)2, DPPP, and Bu3P. In: Synthesis. 2002 ; No. 2. pp. 237-241.
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