Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption

Hatsuo Yamamura, Yuuki Sugiyama, Kensuke Murata, Takanori Yokoi, Ryuji Kurata, Atsushi Miyagawa, Kenji Sakamoto, Keiko Komagoe, Tsuyoshi Inoue, Takashi Katsu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cyclodextrin derivatives are synthesized as membrane-disrupting agents via a microwave-assisted Huisgen reaction. Their ability to permeabilize bacterial membranes depends on the amino substituents and an appropriate balance of hydrophobicity and hydrophilicity, thus enabling the preparation of derivatives with selective toxicity against bacteria.

Original languageEnglish
Pages (from-to)5444-5446
Number of pages3
JournalChemical Communications
Volume50
Issue number41
DOIs
Publication statusPublished - Apr 24 2014

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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    Yamamura, H., Sugiyama, Y., Murata, K., Yokoi, T., Kurata, R., Miyagawa, A., Sakamoto, K., Komagoe, K., Inoue, T., & Katsu, T. (2014). Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption. Chemical Communications, 50(41), 5444-5446. https://doi.org/10.1039/c3cc49543d