Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption

Hatsuo Yamamura, Yuuki Sugiyama, Kensuke Murata, Takanori Yokoi, Ryuji Kurata, Atsushi Miyagawa, Kenji Sakamoto, Keiko Komagoe, Tsuyoshi Inoue, Takashi Katsu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cyclodextrin derivatives are synthesized as membrane-disrupting agents via a microwave-assisted Huisgen reaction. Their ability to permeabilize bacterial membranes depends on the amino substituents and an appropriate balance of hydrophobicity and hydrophilicity, thus enabling the preparation of derivatives with selective toxicity against bacteria. This journal is

Original languageEnglish
Pages (from-to)5444-5446
Number of pages3
JournalChemical Communications
Volume50
Issue number41
DOIs
Publication statusPublished - May 28 2014

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Bearings (structural)
Click Chemistry
Cyclodextrins
Hydrophobic and Hydrophilic Interactions
Derivatives
Membranes
Hydrophilicity
Hydrophobicity
Microwaves
Toxicity
Bacteria

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys
  • Medicine(all)

Cite this

Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption. / Yamamura, Hatsuo; Sugiyama, Yuuki; Murata, Kensuke; Yokoi, Takanori; Kurata, Ryuji; Miyagawa, Atsushi; Sakamoto, Kenji; Komagoe, Keiko; Inoue, Tsuyoshi; Katsu, Takashi.

In: Chemical Communications, Vol. 50, No. 41, 28.05.2014, p. 5444-5446.

Research output: Contribution to journalArticle

Yamamura, H, Sugiyama, Y, Murata, K, Yokoi, T, Kurata, R, Miyagawa, A, Sakamoto, K, Komagoe, K, Inoue, T & Katsu, T 2014, 'Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption', Chemical Communications, vol. 50, no. 41, pp. 5444-5446. https://doi.org/10.1039/c3cc49543d
Yamamura, Hatsuo ; Sugiyama, Yuuki ; Murata, Kensuke ; Yokoi, Takanori ; Kurata, Ryuji ; Miyagawa, Atsushi ; Sakamoto, Kenji ; Komagoe, Keiko ; Inoue, Tsuyoshi ; Katsu, Takashi. / Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption. In: Chemical Communications. 2014 ; Vol. 50, No. 41. pp. 5444-5446.
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