Synthesis of actiketal, a glutarimide antibiotic

Hiromasa Kiyota, Yuko Shimizu, Takayuki Oritani

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The first synthesis of actiketal (RK-441S), an antibiotic from Streptomyces pulveraceus subsp. epiderstagenes, was achieved from 5,7- dimethylbenzofuran and dimethyl glutaconate via palladium-assisted coupling reaction as a key step. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)5887-5890
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number31
Publication statusPublished - Jul 29 2000
Externally publishedYes

Fingerprint

Palladium
Streptomyces
Anti-Bacterial Agents
glutarimide
actiketal
glutaconic acid

Keywords

  • Acetals
  • Antibiotics
  • Glutarimides
  • Polyketides

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Kiyota, H., Shimizu, Y., & Oritani, T. (2000). Synthesis of actiketal, a glutarimide antibiotic. Tetrahedron Letters, 41(31), 5887-5890.

Synthesis of actiketal, a glutarimide antibiotic. / Kiyota, Hiromasa; Shimizu, Yuko; Oritani, Takayuki.

In: Tetrahedron Letters, Vol. 41, No. 31, 29.07.2000, p. 5887-5890.

Research output: Contribution to journalArticle

Kiyota, H, Shimizu, Y & Oritani, T 2000, 'Synthesis of actiketal, a glutarimide antibiotic', Tetrahedron Letters, vol. 41, no. 31, pp. 5887-5890.
Kiyota H, Shimizu Y, Oritani T. Synthesis of actiketal, a glutarimide antibiotic. Tetrahedron Letters. 2000 Jul 29;41(31):5887-5890.
Kiyota, Hiromasa ; Shimizu, Yuko ; Oritani, Takayuki. / Synthesis of actiketal, a glutarimide antibiotic. In: Tetrahedron Letters. 2000 ; Vol. 41, No. 31. pp. 5887-5890.
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