Synthesis of actiketal, a glutarimide antibiotic

Hiromasa Kiyota, Yuko Shimizu, Takayuki Oritani

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

The first synthesis of actiketal (RK-441S), an antibiotic from Streptomyces pulveraceus subsp. epiderstagenes, was achieved from 5,7- dimethylbenzofuran and dimethyl glutaconate via palladium-assisted coupling reaction as a key step. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)5887-5890
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number31
DOIs
Publication statusPublished - Jul 29 2000

Keywords

  • Acetals
  • Antibiotics
  • Glutarimides
  • Polyketides

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of actiketal, a glutarimide antibiotic'. Together they form a unique fingerprint.

Cite this