Synthesis of a novel artemisinin analogue having potent antimalarial activity

Kiyosei Takasu; Ruriko Katagiri; Yuko Tanaka; Masahiro Toyota; Hye Sook Kim; Yusuke Wataya; Masataka Ihara

doi:10.3987/com-00-s(i)91

Synthesis of a novel artemisinin analogue having potent antimalarial activity

Kiyosei Takasu, Ruriko Katagiri, Yuko Tanaka, Masahiro Toyota, Hye Sook Kim, Yusuke Wataya, Masataka Ihara

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

An artemisinin analogue containing 1,2,4-trioxane structure was designed and synthesized. The compound exhibited significant and selective in vitro antimalarial activity.

Original language	English
Pages (from-to)	607-610
Number of pages	4
Journal	Heterocycles
Volume	54
Issue number	2
DOIs	https://doi.org/10.3987/com-00-s(i)91
Publication status	Published - Feb 1 2001

Keywords

1,2,4-Trioxane
Antimalarial Activity
Artemisinin
Octalone

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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title = "Synthesis of a novel artemisinin analogue having potent antimalarial activity",

abstract = "An artemisinin analogue containing 1,2,4-trioxane structure was designed and synthesized. The compound exhibited significant and selective in vitro antimalarial activity.",

keywords = "1,2,4-Trioxane, Antimalarial Activity, Artemisinin, Octalone",

author = "Kiyosei Takasu and Ruriko Katagiri and Yuko Tanaka and Masahiro Toyota and Kim, {Hye Sook} and Yusuke Wataya and Masataka Ihara",

year = "2001",

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T1 - Synthesis of a novel artemisinin analogue having potent antimalarial activity

AU - Takasu, Kiyosei

AU - Katagiri, Ruriko

AU - Tanaka, Yuko

AU - Toyota, Masahiro

AU - Kim, Hye Sook

AU - Wataya, Yusuke

AU - Ihara, Masataka

PY - 2001/2/1

Y1 - 2001/2/1

N2 - An artemisinin analogue containing 1,2,4-trioxane structure was designed and synthesized. The compound exhibited significant and selective in vitro antimalarial activity.

AB - An artemisinin analogue containing 1,2,4-trioxane structure was designed and synthesized. The compound exhibited significant and selective in vitro antimalarial activity.

KW - 1,2,4-Trioxane

KW - Antimalarial Activity

KW - Artemisinin

KW - Octalone

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U2 - 10.3987/com-00-s(i)91

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M3 - Article

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JO - Heterocycles

JF - Heterocycles

SN - 0385-5414

IS - 2

ER -

Synthesis of a novel artemisinin analogue having potent antimalarial activity

Abstract

Keywords

ASJC Scopus subject areas

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