Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization

Toshimasa Hamamoto, Masahiko Sisido, Takashi Ohtsuki, Masumi Taki

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.

Original languageEnglish
Pages (from-to)9116-9118
Number of pages3
JournalChemical Communications
Volume47
Issue number32
DOIs
Publication statusPublished - Aug 28 2011

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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