Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization

Toshimasa Hamamoto; Masahiko Sisido; Takashi Ohtsuki; Masumi Taki

doi:10.1039/c1cc12196k

Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization

Toshimasa Hamamoto, Masahiko Sisido, Takashi Ohtsuki, Masumi Taki

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.

Original language	English
Pages (from-to)	9116-9118
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	32
DOIs	https://doi.org/10.1039/c1cc12196k
Publication status	Published - Aug 28 2011

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization",

abstract = "By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.",

author = "Toshimasa Hamamoto and Masahiko Sisido and Takashi Ohtsuki and Masumi Taki",

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AU - Hamamoto, Toshimasa

AU - Sisido, Masahiko

AU - Ohtsuki, Takashi

AU - Taki, Masumi

PY - 2011/8/28

Y1 - 2011/8/28

N2 - By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.

AB - By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.

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JO - Chemical Communications

JF - Chemical Communications

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Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization

Abstract

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