Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization

Toshimasa Hamamoto; Masahiko Sisido; Takashi Ohtsuki; Masumi Taki

doi:10.1039/c1cc12196k

Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization

Toshimasa Hamamoto, Masahiko Sisido, Takashi Ohtsuki, Masumi Taki

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.

Original language	English
Pages (from-to)	9116-9118
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	32
DOIs	https://doi.org/10.1039/c1cc12196k
Publication status	Published - Aug 28 2011

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c1cc12196k

Cite this

@article{bbc1375a4ff440afad6ddb4c8f89b5fa,

title = "Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization",

abstract = "By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.",

author = "Toshimasa Hamamoto and Masahiko Sisido and Takashi Ohtsuki and Masumi Taki",

year = "2011",

month = aug,

day = "28",

doi = "10.1039/c1cc12196k",

language = "English",

volume = "47",

pages = "9116--9118",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "32",

}

TY - JOUR

T1 - Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization

AU - Hamamoto, Toshimasa

AU - Sisido, Masahiko

AU - Ohtsuki, Takashi

AU - Taki, Masumi

PY - 2011/8/28

Y1 - 2011/8/28

N2 - By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.

AB - By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.

UR - http://www.scopus.com/inward/record.url?scp=79960975797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960975797&partnerID=8YFLogxK

U2 - 10.1039/c1cc12196k

DO - 10.1039/c1cc12196k

M3 - Article

C2 - 21735001

AN - SCOPUS:79960975797

VL - 47

SP - 9116

EP - 9118

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 32

ER -

Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this