Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization

Toshimasa Hamamoto; Masahiko Sisido; Takashi Ohtsuki; Masumi Taki

doi:10.1039/c1cc12196k

Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization

Toshimasa Hamamoto, Masahiko Sisido, Takashi Ohtsuki, Masumi Taki

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.

Original language	English
Pages (from-to)	9116-9118
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	32
DOIs	https://doi.org/10.1039/c1cc12196k
Publication status	Published - Aug 28 2011

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ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Cite this

Hamamoto, T., Sisido, M., Ohtsuki, T., & Taki, M. (2011). Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization. Chemical Communications, 47(32), 9116-9118. https://doi.org/10.1039/c1cc12196k

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Access to Document

10.1039/c1cc12196k